Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Phenethyl Isobutyrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
No significant safety concerns at typical fragrance use levels.
Regulatory Flags
Frequently Asked Questions
Is Phenethyl Isobutyrate safe in cosmetics?
No significant safety concerns at typical fragrance use levels. The EU classifies Phenethyl Isobutyrate as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.
Is Phenethyl Isobutyrate allowed in the EU?
Phenethyl Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenethyl Isobutyrate do in cosmetics?
Phenethyl Isobutyrate functions as: Fragrance (perfuming agent). It is classified as a cosmetic ingredient in our database. CAS number: 103-48-0.
What is the Margin of Safety for Phenethyl Isobutyrate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Phenethyl Isobutyrate?
The NOAEL (No Observed Adverse Effect Level) for Phenethyl Isobutyrate is 1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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