What is the NOAEL for Dibenzyl ether?
Dibenzyl ether has 16 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dibenzyl ether
Also known as: 1,1-[Oxybis(methylene)]bisbenzene, 1,1'-(Oxydimethanediyl)dibenzene, 4-06-00-02240, BA (VAN), BRN 1911156 (+9 more)
CAS 103-50-4
Dibenzyl ether (CAS 103-50-4) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
16
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Dibenzyl ether
CAS Number
103-50-4
Molecular Formula
C14H14O
InChI Key
MHDVGSVTJDSBDK-UHFFFAOYSA-N
Monoisotopic Mass
198.104465
Synonyms
1,1-[Oxybis(methylene)]bisbenzene1,1'-(Oxydimethanediyl)dibenzene4-06-00-02240BA (VAN)BRN 1911156EINECS 203-118-2Ether, dibenzylFEMA No. 2371FEMA Number 23711,1-Oxybismethylene, bis benzene1,1'-(Oxybis(methylene))bisbenzenePlasticator BA
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
FragranceFlavouring and nutrientPlasticizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 65.83 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 150 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| =43.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 37.78 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 1136 | uM | EC3 | Dermal | - | NTP ICE skin sensitization |
| 2O6CNO27RJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 244 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 3.37 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =2500 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 196 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| 3.33 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 62 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 620 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 16 of 16 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dibenzyl ether | 203-118-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL152299
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Dibenzyl ether?
Dibenzyl ether appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Dibenzyl ether used in cosmetics?
Yes, Dibenzyl ether is also indexed as a cosmetic ingredient under the name Dibenzyl Ether. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dibenzyl ether come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Dibenzyl ether used outside industrial chemicals?
Dibenzyl ether also appears in cosmetics, pharmaceutical, cannabis databases.