Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Dibenzyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 3.33 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 620 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 620 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 62 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 196 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 3.33 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 620 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Confirmed skin sensitizer with IFRA concentration restrictions by product category; dermal absorption of 42.20% is significant requiring QRA2 methodology for max use level determination; eye irritant.
Regulatory Flags
Frequently Asked Questions
Is Dibenzyl Ether safe in cosmetics?
Confirmed skin sensitizer with IFRA concentration restrictions by product category; dermal absorption of 42.20% is significant requiring QRA2 methodology for max use level determination; eye irritant. The EU classifies Dibenzyl Ether as "permitted". Safety rating: MODERATE. 7 toxicological study endpoint(s) are available in our database.
Is Dibenzyl Ether allowed in the EU?
Dibenzyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dibenzyl Ether do in cosmetics?
Dibenzyl Ether functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 103-50-4.
What is the Margin of Safety for Dibenzyl Ether?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dibenzyl Ether?
The NOAEL (No Observed Adverse Effect Level) for Dibenzyl Ether is 3.33 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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