What is the NOAEL for 2-Phenoxyethyl isobutyrate?
2-Phenoxyethyl isobutyrate has 7 NOAEL studies in the database. The lowest reported value is 17.63 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Phenoxyethyl isobutyrate
Also known as: Phenoxyethyl isobutyrate, Propanoic acid, 2-methyl-, 2-phenoxyethyl ester, BRN 2215248, EINECS 203-127-1, FEMA No. 2873 (+4 more)
CAS 103-60-6
2-Phenoxyethyl isobutyrate (CAS 103-60-6) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
7
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
2-Phenoxyethyl isobutyrate
CAS Number
103-60-6
Molecular Formula
C12H16O3
InChI Key
MJTPMXWJHPOWGH-UHFFFAOYSA-N
Monoisotopic Mass
208.109944
Synonyms
Phenoxyethyl isobutyratePropanoic acid, 2-methyl-, 2-phenoxyethyl esterBRN 2215248EINECS 203-127-1FEMA No. 2873Isobutyric acid, 2-phenoxyethyl esterNSC 2272102-Phenoxyethyl 2-methylpropanoateUNII-43ENB1627Z
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
60 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =17.63 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 43ENB1627Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 310 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-phenoxyethyl isobutyrate | 203-127-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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ChEMBL / DailyMed
CHEMBL3182892
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Phenoxyethyl isobutyrate?
2-Phenoxyethyl isobutyrate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is 2-Phenoxyethyl isobutyrate used in cosmetics?
Yes, 2-Phenoxyethyl isobutyrate is also indexed as a cosmetic ingredient under the name Phenoxyethyl Isobutyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Phenoxyethyl isobutyrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Phenoxyethyl isobutyrate used outside industrial chemicals?
2-Phenoxyethyl isobutyrate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.