Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Phenoxyethyl Isobutyrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | >1000 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOEL | 1000 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOEL | 500 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOEL | 500 mg/kg bw/day | dermal | - | dermal | REACH |
Expert Verdict
Good thermal stability with low volatility; used primarily as a fragrance fixative and must comply with IFRA category limits.
Regulatory Flags
Frequently Asked Questions
Is Phenoxyethyl Isobutyrate safe in cosmetics?
Good thermal stability with low volatility; used primarily as a fragrance fixative and must comply with IFRA category limits. The EU classifies Phenoxyethyl Isobutyrate as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.
Is Phenoxyethyl Isobutyrate allowed in the EU?
Phenoxyethyl Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenoxyethyl Isobutyrate do in cosmetics?
Phenoxyethyl Isobutyrate functions as: Fragrance ingredient; perfume fixative. It is classified as a cosmetic ingredient in our database. CAS number: 103-60-6.
What is the Margin of Safety for Phenoxyethyl Isobutyrate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Phenoxyethyl Isobutyrate?
The NOAEL (No Observed Adverse Effect Level) for Phenoxyethyl Isobutyrate is >1000 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 4 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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