What is the GHS hazard classification for Octyl gallate?
Octyl gallate (CAS 1034-01-1) is classified under EU CLP Annex VI as Acute Tox. 4 *; Skin Sens. 1 with signal word Warning. Hazard statements: H302; H317. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
Cosmetic Ingredient
Octyl gallate
Also known as: Benzoic acid, 3,4,5-trihydroxy-, octyl ester, 4-10-00-02005, BRN 2132305, EINECS 213-853-0, NSC 97419 (+7 more)
CAS 1034-01-1
Octyl gallate (CAS 1034-01-1) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H317. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
NOAEL studies
NOAEL studies
17
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Octyl gallate
CAS Number
1034-01-1
Molecular Formula
C15H22O5
InChI Key
NRPKURNSADTHLJ-UHFFFAOYSA-N
Monoisotopic Mass
282.146724
Synonyms
Benzoic acid, 3,4,5-trihydroxy-, octyl ester4-10-00-02005BRN 2132305EINECS 213-853-0NSC 97419n-Octyl ester of 3,4,5-trihydroxybenzoic acidProgallin OStabilizer GA 8Oktylester kyseliny galloveUNII-079IIA2811Gallic acid octyl estern-Octyl gallate
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Skin Sens. 1 | H302; H317 | GHS07 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Antioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 4.889 | uM | AC50 | - | - | NTP ICE endocrine |
| 13.41 | uM | AC50 | - | - | NTP ICE endocrine |
| 8.617 | uM | ACC | - | - | NTP ICE endocrine |
| 10.06 | uM | ACC | - | - | NTP ICE endocrine |
| 230 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 079IIA2811 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.000904 | fraction | Fu | - | Human | NTP ICE adme parameters |
| =1960 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| =2710 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0144 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0768 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.369 | unitless | Model Score | - | - | NTP ICE endocrine |
| 125 | mg/kg bw/day | NOAEL | oral | dog | COSMOS DB |
| 150 | mg/kg bw/day | NOAEL | oral | dog | COSMOS DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
Showing 17 of 17 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
OCTYL_GALLATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
7
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
E311 — ADI: 1.4 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Octyl gallate?
Octyl gallate has 17 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
What regulatory lists include Octyl gallate?
Octyl gallate appears on 3 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), animal_products, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Octyl gallate used in cosmetics?
Yes, Octyl gallate is also indexed as a cosmetic ingredient under the name Caprylyl Gallate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Octyl gallate come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Octyl gallate used outside industrial chemicals?
Octyl gallate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.