Moderate Cosmetic Ingredient NOAEL Data

Caprylyl Gallate

INCI: CAPRYLYL GALLATE

CAS Number
1034-01-1
Function
Antioxidant, preservative booster, chelating agent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes GRAS (Generally Recognized As Safe) as antioxidant; permitted in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Caprylyl Gallate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 125 mg/kg bw/day oral dog Subchronic COSMOS_DB
NOAEL 150 mg/kg bw/day oral dog Subchronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 125 mg/kg bw/day oral rat Multigeneration Reproductive COSMOS_DB
NOAEL 125 mg/kg bw/day oral rat Reproductive-developmental COSMOS_DB
NOAEL 150 mg/kg bw/day oral rat Multigeneration Reproductive COSMOS_DB
dose_tested 500 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 125 mg/kg bw/day oral dog Subchronic COSMOS_DB
dose_tested 150 mg/kg bw/day oral dog Subchronic COSMOS_DB

Expert Verdict

Potential contact allergen at high concentrations; phenolic compound sensitivity

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Concern Level: Moderate

Regulatory Flags

potential-allergen preservative fda_food_additive jecfa_concern

Frequently Asked Questions

Is Caprylyl Gallate safe in cosmetics?

Potential contact allergen at high concentrations; phenolic compound sensitivity The EU classifies Caprylyl Gallate as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.

Is Caprylyl Gallate allowed in the EU?

Caprylyl Gallate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Caprylyl Gallate do in cosmetics?

Caprylyl Gallate functions as: Antioxidant, preservative booster, chelating agent. It is classified as a cosmetic ingredient in our database. CAS number: 1034-01-1.

What is the Margin of Safety for Caprylyl Gallate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Caprylyl Gallate?

The NOAEL (No Observed Adverse Effect Level) for Caprylyl Gallate is 500 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Caprylyl Gallate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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