Is Caprylyl Gallate safe in cosmetics?
Caprylyl Gallate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Caprylyl Gallate
Also known as: Benzoic acid, 3,4,5-trihydroxy-, octyl ester, 4-10-00-02005, BRN 2132305, EINECS 213-853-0, NSC 97419 (+7 more)
INCI: CAPRYLYL GALLATE
Caprylyl Gallate (CAS 1034-01-1) is a cosmetic cosmetic ingredient functioning as Antioxidant, preservative booster, chelating agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1034-01-1 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, preservative booster, chelating agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
octyl 3,4,5-trihydroxybenzoate
InChIKey
NRPKURNSADTHLJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS (Generally Recognized As Safe) as antioxidant; permitted in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Caprylyl Gallate.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Acute Tox. 4 *; Skin Sens. 1
Hazard Statements
- H302 Harmful if swallowed
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: other
Receptor targets: ERα, ERβ, AR
LOEC: 10 µM
EU status: allowed (max 0.1%)
agonist (ER, weak); antagonist (AR)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (2)
JECFA Evaluation
OCTYL GALLATE | 1996 | NO ADI ALLOCATED | The temporary ADI allocated at the forty-first meeting (1993) was not extended | TRS 868-JECFA 46/15
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Caprylyl Gallate.
Regulatory Flags
potential-allergen
preservative
fda_food_additive
jecfa_concern
Known Synonyms
Benzoic acid, 3,4,5-trihydroxy-, octyl ester
4-10-00-02005
BRN 2132305
EINECS 213-853-0
NSC 97419
n-Octyl ester of 3,4,5-trihydroxybenzoic acid
Progallin O
Stabilizer GA 8
Oktylester kyseliny gallove
UNII-079IIA2811
Gallic acid octyl ester
n-Octyl gallate
Chemical Function
Antioxidant
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
animal_products
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
OCTYL_GALLATE
ChEMBL ID
CHEMBL277346
Frequently Asked Questions
Is Caprylyl Gallate allowed in the EU?
Caprylyl Gallate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Caprylyl Gallate do in cosmetics?
Caprylyl Gallate functions as: Antioxidant, preservative booster, chelating agent. It is classified as a cosmetic ingredient in our database. CAS number: 1034-01-1.
Is Caprylyl Gallate used outside cosmetics?
Caprylyl Gallate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Caprylyl Gallate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Dipotassium EDTA
Excellent
Same category
Chelating agent; preservative booster
Glyceryl Caprylate/Caprate
Excellent
Same category
Emulsifier; Humectant; Softener and c...
Hexanediol (1,2-Hexanediol)
Excellent
Same category
Solvent, humectant, emollient, preser...
Phenethyl Alcohol
Excellent
Same category
Fragrance ingredient; preservative (a...
Polyepsilon-Lysine
Excellent
Same category
Preservative (antimicrobial); hair co...
Sodium Lauriminodipropionate Tocopheryl Phosphate
Excellent
Same category
Antistatic, cleansing, foaming, hair ...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
Ethylhexyl Gallate
Moderate
Chemical family
Antioxidant
CAPE ALOE
Good
Browse nearby
Skin Conditioning
CAPSAICIN
Good
Browse nearby
Fragrance, Skin Conditioning
Is Caprylyl Gallate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Caprylyl Gallate in your formulation.