What is the NOAEL for 4-Methoxybenzyl acetate?
4-Methoxybenzyl acetate has 24 NOAEL studies in the database. The lowest reported value is 2 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Methoxybenzyl acetate
Also known as: Benzenemethanol, 4-methoxy-, acetate, 4-Anisyl acetate, 4-Methoxybenzenenemethyl acetate, Cassie ketone, Anisyl acetate (+10 more)
CAS 104-21-2
4-Methoxybenzyl acetate (CAS 104-21-2) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
24
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
4-Methoxybenzyl acetate
CAS Number
104-21-2
DTXSID
DTXSID1044770
Molecular Formula
C10H12O3
InChI Key
HFNGYHHRRMSKEU-UHFFFAOYSA-N
Monoisotopic Mass
180.078644
Synonyms
Benzenemethanol, 4-methoxy-, acetate4-Anisyl acetate4-Methoxybenzenenemethyl acetateCassie ketoneAnisyl acetateBenzenemethanol, 4-methoxy-, 1-acetateAnisyl acetate, p-isomerBenzyl alcohol, p-methoxy-, acetateEINECS 203-185-8FEMA No. 2098Methoxybenzyl acetate, p-p-Methoxybenzyl alcohol acetate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
59 records
FragranceNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 24 of 24 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| =2.468 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 2GEC7KBO31 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2GEC7KBO31 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2GEC7KBO31 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2GEC7KBO31 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 4 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 8 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 1620 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3240 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1296 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| =20 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =20 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =20 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =400 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 24 of 24 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | p-methoxybenzyl acetate | 203-185-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3184606
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 4-Methoxybenzyl acetate?
4-Methoxybenzyl acetate appears on 5 regulatory/inventory lists including Australia; Food and drug - smoking-related products, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), IFRA Transparency, and 2 more. Source: EPA CPDat.
Is 4-Methoxybenzyl acetate used in cosmetics?
Yes, 4-Methoxybenzyl acetate is also indexed as a cosmetic ingredient under the name Anisyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Methoxybenzyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-Methoxybenzyl acetate used outside industrial chemicals?
4-Methoxybenzyl acetate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.