Is Anisyl Acetate safe in cosmetics?
Anisyl Acetate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Anisyl Acetate
Also known as: Benzenemethanol, 4-methoxy-, acetate, 4-Anisyl acetate, 4-Methoxybenzenenemethyl acetate, Cassie ketone, Benzenemethanol, 4-methoxy-, 1-acetate (+9 more)
INCI: ANISYL ACETATE
Anisyl Acetate (CAS 104-21-2) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 104-21-2 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
(4-methoxyphenyl)methyl acetate
InChIKey
HFNGYHHRRMSKEU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA cosmetic restrictions; FEMA GRAS #2098 for flavor use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Anisyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Anisyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =200 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =400 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Anisyl Acetate across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
2592 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [96] RIFM (1971): RIFM report number 1805, September 27, unpublished.
HRIPT Human Patch Test Studies
4 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
| HMT | - | 0 | 2592 | - | - |
| HMT | - | 0 | 2700 | - | - |
| HMT | - | 0 | 6750 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
fragrance_ifra
{"cas_number": "104-21-2", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.11", "ifra_max_use_level_category_4_pct": "1.8", "ifra_max_use_level_category_7_pct": "0.26", "ifra_max_use_level_category_11_pct": "0.052", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_po…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
873
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ANISYL ACETATE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CASSIE KETONE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
p-METHOXYBENZYL ACETATE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
No specific technical function
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Anisyl Acetate.
Regulatory Flags
ALLERGEN
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Anisyl Acetate by CAS number or substance name.
Studies
3
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
400 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Benzenemethanol, 4-methoxy-, acetate
4-Anisyl acetate
4-Methoxybenzenenemethyl acetate
Cassie ketone
Benzenemethanol, 4-methoxy-, 1-acetate
Anisyl acetate, p-isomer
Benzyl alcohol, p-methoxy-, acetate
EINECS 203-185-8
FEMA No. 2098
Methoxybenzyl acetate, p-
p-Methoxybenzyl alcohol acetate
NSC 46102
4-Methoxybenzenemethanol, acetate
UNII-2GEC7KBO31
Chemical Function
Fragrance
No specific technical function
Flavouring and nutrient
Regulatory Lists
Australia; Food and drug - smoking-related products
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
Europe
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184606
Frequently Asked Questions
Is Anisyl Acetate allowed in the EU?
Anisyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Anisyl Acetate do in cosmetics?
Anisyl Acetate functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 104-21-2.
What is the NOAEL for Anisyl Acetate?
The NOAEL (No Observed Adverse Effect Level) for Anisyl Acetate is =100 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Anisyl Acetate used outside cosmetics?
Anisyl Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Anisyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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