Good Cosmetic Ingredient NOAEL Data

Anisyl Acetate

INCI: ANISYL ACETATE

CAS Number
104-21-2
Function
Perfuming
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No FDA cosmetic restrictions; FEMA GRAS #2098 for flavor use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Anisyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 400 mg/kg bw/day oral rat oral REACH
NOAEL 200 mg/kg bw/day oral rat oral REACH

Expert Verdict

Anisyl Acetate is permitted in EU cosmetics but is a confirmed skin sensitizer requiring strict IFRA/RIFM use limits per product category.

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Concern Level: High

Regulatory Flags

ALLERGEN ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Anisyl Acetate safe in cosmetics?

Anisyl Acetate is permitted in EU cosmetics but is a confirmed skin sensitizer requiring strict IFRA/RIFM use limits per product category. The EU classifies Anisyl Acetate as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Anisyl Acetate allowed in the EU?

Anisyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Anisyl Acetate do in cosmetics?

Anisyl Acetate functions as: Perfuming. It is classified as a Cosmetic Ingredient in our database. CAS number: 104-21-2.

What is the Margin of Safety for Anisyl Acetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Anisyl Acetate?

The NOAEL (No Observed Adverse Effect Level) for Anisyl Acetate is 400 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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