What is the NOAEL for Chlorphenesin?
Chlorphenesin has 4 NOAEL studies in the database. The lowest reported value is 1.64 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Chlorphenesin
Also known as: 3-(4-CHLOROPHENOXY)-1,2-PROPANEDIOL, 1,2-Propanediol, 3-(4-chlorophenoxy)-, 2-Chlorphenesin, p-Chlorophenyl glyceryl ether, 4-06-00-00831 (+8 more)
CAS 104-29-0
Chlorphenesin (CAS 104-29-0) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Chlorphenesin is classified GHS Danger (H302, H315, H318, H319, H332, H335) in the chemicals database but is restricted in EU cosmetics at max 0.3%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
4
SOURCE
Chemical inventory jurisdictions
Regulatory lists
7
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Chlorphenesin
CAS Number
104-29-0
Molecular Formula
C9H11ClO3
InChI Key
MXOAEAUPQDYUQM-UHFFFAOYSA-N
Monoisotopic Mass
202.039672
Synonyms
3-(4-CHLOROPHENOXY)-1,2-PROPANEDIOL1,2-Propanediol, 3-(4-chlorophenoxy)-2-Chlorphenesinp-Chlorophenyl glyceryl ether4-06-00-00831BRN 2210845ChlorophenesinEINECS 203-192-6ChlorphenesinumUNII-I670DAL4SZ3-(p-chlorophenoxy)-1,2-propanediolglycerol alpha-p-chlorophenyl ether
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
17 records
BiocidePreservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | European Commission | CosIng |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.64 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| I670DAL4SZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ~100 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| ~100 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Chlorphenesin | 203-192-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.3%
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL388751
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include Chlorphenesin?
Chlorphenesin appears on 6 regulatory/inventory lists including Europe; Personal care, pharmaceutical, active_ingredient; Europe; Pesticides, and 3 more. Source: EPA CPDat.
Is Chlorphenesin used in cosmetics?
Yes, Chlorphenesin is also indexed as a cosmetic ingredient under the name Chlorphenesin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Chlorphenesin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Chlorphenesin have different safety status in cosmetics vs industrial chemicals?
Chlorphenesin is classified GHS Danger (H302, H315, H318, H319, H332, H335) in the chemicals database but is restricted in EU cosmetics at max 0.3%.
Is Chlorphenesin used outside industrial chemicals?
Chlorphenesin also appears in cosmetics, pharmaceutical databases.