Chlorphenesin
INCI: CHLORPHENESIN
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Chlorphenesin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | ca.100 mg/kg bw/day | oral | rat | oral | REACH |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
ailable data demonstrated an absence of toxicity. The Panel concluded that chlorphenesin is safe in the present practices of use and concentration. Keywords chlorphenesin, safety, cosmetics Introduction As stated in the International Cosmetic Ingredient Dictionary and Handbook,1 chlorphenesin fu
Sensitization Profile
Contact sensitization data for Chlorphenesin based on clinical patch test studies and IFRA standards.
Source: ESSCA; IVDK; NACDG
Dermal Penetration Profile
Skin absorption and penetration characteristics of Chlorphenesin, relevant to systemic exposure and MoS calculations.
Source: SCCS Opinion
Expert Verdict
Broad-spectrum preservative with better ocular compatibility than benzalkonium chloride (BAK), making it a preferred option in eye cosmetic formulations. EU Annex V listed at a maximum of 0.3%. Ophthalmological literature specifically identifies chlorphenesin alongside phenoxyethanol as alternatives to BAK for eye-area products, given BAK's documented corneal and conjunctival toxicity. Does not carry the tear film destabilization or meibomian gland damage associated with BAK. Suitable for mascara and eye-area rinse-off product preservation.
Regulatory Flags
Frequently Asked Questions
Is Chlorphenesin safe in cosmetics?
Broad-spectrum preservative with better ocular compatibility than benzalkonium chloride (BAK), making it a preferred option in eye cosmetic formulations. EU Annex V listed at a maximum of 0.3%. Ophthalmological literature specifically identifies chlorphenesin alongside phenoxyethanol as alternatives to BAK for eye-area products, given BAK's documented corneal and conjunctival toxicity. Does not carry the tear film destabilization or meibomian gland damage associated with BAK. Suitable for mascara and eye-area rinse-off product preservation. The EU classifies Chlorphenesin as "restricted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is Chlorphenesin allowed in the EU?
Chlorphenesin EU regulatory status: restricted. Maximum allowed concentration: 0.3%. This is based on EU Regulation 1223/2009 and its amendments.
What does Chlorphenesin do in cosmetics?
Chlorphenesin functions as: Preservative; antimicrobial. It is classified as a Preservative in our database. CAS number: 104-29-0.
What is the Margin of Safety for Chlorphenesin?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Chlorphenesin?
The NOAEL (No Observed Adverse Effect Level) for Chlorphenesin is ca.100 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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