What is the NOAEL for 3-Phenylpropanal?
3-Phenylpropanal has 10 NOAEL studies in the database. The lowest reported value is LP1E86N30T UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
3-Phenylpropanal
Also known as: Hydrocinnamaldehyde, 4-07-00-00692, BRN 1071910, EINECS 203-211-8, FEMA No. 2887 (+5 more)
CAS 104-53-0
3-Phenylpropanal (CAS 104-53-0) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
3-Phenylpropanal
CAS Number
104-53-0
DTXSID
DTXSID0047610
Molecular Formula
C9H10O
InChI Key
YGCZTXZTJXYWCO-UHFFFAOYSA-N
Monoisotopic Mass
134.073165
Synonyms
Hydrocinnamaldehyde4-07-00-00692BRN 1071910EINECS 203-211-8FEMA No. 2887Hydrocinnamylaldehydebeta-Phenylpropionaldehyde3-PhenylpropylaldehydePropionaidehyde, 3-phenyl-UNII-LP1E86N30T
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
13 records
FragranceNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| LP1E86N30T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LP1E86N30T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LP1E86N30T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LP1E86N30T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5184 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =275 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =275 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DIHYDROCINNAMALDEHYDE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 3-Phenylpropanal?
3-Phenylpropanal appears on 4 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is 3-Phenylpropanal used in cosmetics?
Yes, 3-Phenylpropanal is also indexed as a cosmetic ingredient under the name Hydrocinnamaldehyde. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3-Phenylpropanal come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 3-Phenylpropanal used outside industrial chemicals?
3-Phenylpropanal also appears in cosmetics, pharmaceutical, food safety, cannabis databases.