Is Hydrocinnamaldehyde safe in cosmetics?
Hydrocinnamaldehyde has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hydrocinnamaldehyde
Also known as: 4-07-00-00692, BRN 1071910, EINECS 203-211-8, FEMA No. 2887, Hydrocinnamylaldehyde (+4 more)
Hydrocinnamaldehyde (CAS 104-53-0) is a cosmetic cosmetic ingredient functioning as Flavouring and nutrient; Fragrance; No specific technical function. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 104-53-0 →
Auto-generated CPSR Part A draft with source citations
Function
Flavouring and nutrient; Fragrance; No specific technical function
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-phenylpropanal
InChIKey
YGCZTXZTJXYWCO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydrocinnamaldehyde.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
11.61%
DPRA Lys %
11.4%
KeratinoSens IC50
551.539 µM
hCLAT CV75
86.4 µg/mL
NESIL
5184 µg/cm²
GHS: 1B
Human: positive
Source: DPRA: Unilever commissioned, Charles River | Unilever commissioned, IIVS; KS: Unilever commissioned, Charles River; hCLAT: Unilever commissioned, IIVS; HPPT: [50] Kligman AM (1973): Report to RIFM, 27 July, unpublished.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5184 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
645
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-PHENYLPROPIONALDEHYDE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/22 | FAS 46-JECFA 55/79
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BENZYLACETALDEHYDE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/22 | FAS 46-JECFA 55/79
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HYDROCINNAMALDEHYDE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/22 | FAS 46-JECFA 55/79
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
No specific technical function
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Hydrocinnamaldehyde.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
4-07-00-00692
BRN 1071910
EINECS 203-211-8
FEMA No. 2887
Hydrocinnamylaldehyde
beta-Phenylpropionaldehyde
3-Phenylpropylaldehyde
Propionaidehyde, 3-phenyl-
UNII-LP1E86N30T
Chemical Function
Fragrance
No specific technical function
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australia; Food and drug - smoking-related products
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIHYDROCINNAMALDEHYDE
ChEMBL ID
CHEMBL440161
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
3-PHENYLPROPIONALDEHYDE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Hydrocinnamaldehyde allowed in the EU?
Hydrocinnamaldehyde EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydrocinnamaldehyde do in cosmetics?
Hydrocinnamaldehyde functions as: Flavouring and nutrient; Fragrance; No specific technical function. It is classified as a cosmetic ingredient in our database. CAS number: 104-53-0.
Is Hydrocinnamaldehyde used outside cosmetics?
Hydrocinnamaldehyde also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hydrocinnamaldehyde compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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