What is the NOAEL for 3-Phenyl-2-propen-1-ol?
3-Phenyl-2-propen-1-ol has 97 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3-Phenyl-2-propen-1-ol
Also known as: Cinnamyl alcohol, 1-06-00-00281, BRN 1903999, EINECS 203-212-3, FEMA No. 2294 (+6 more)
CAS 104-54-1
3-Phenyl-2-propen-1-ol (CAS 104-54-1) is a chemical substance. Key regulatory status: REACH registered, 28 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
97
SOURCE
Chemical inventory jurisdictions
Regulatory lists
28
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
16 fields
Name
3-Phenyl-2-propen-1-ol
CAS Number
104-54-1
Molecular Formula
C9H10O
InChI Key
OOCCDEMITAIZTP-UHFFFAOYSA-N
Monoisotopic Mass
134.073165
Synonyms
Cinnamyl alcohol1-06-00-00281BRN 1903999EINECS 203-212-3FEMA No. 2294gamma-Phenylallyl alcoholPhenyl-2-propen-1-olPropenoic acid, 3-phenyl-, (trans)-Zimtalcohol3-Fenyl-2-propen-1-olAlkohol skoricovy
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceFlavouring and nutrientNo specific technical functionProcessing aids not otherwise specifiedDeodorizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
28 records
| List | Keyword | Source |
|---|---|---|
| Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; detected; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - dishwasher and dishes; Cleaning products and household care - laundry and fabric treatment - fabric softener; detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| Europe; Personal care; restricted | European Commission | CosIng |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 97 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 62.97 | uM | AC50 | - | - | NTP ICE endocrine |
| 42.08 | uM | ACC | - | - | NTP ICE endocrine |
| 97 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 196.6 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 21.41 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 73 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 76.8 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 101.6 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 147 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 109.7 | ug/mL | CV70 | Dermal | - | NTP ICE skin sensitization |
| 206.9 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 350 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 1.389 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1.65 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1.786 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 2.167 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 2.333 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 2.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 3.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 4.167 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| range4.2 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 4.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 5.4 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 5.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 5.75 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 7.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 8.1 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 14 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 1.111 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 1.429 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 1.667 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 2 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 3.333 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 4 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 5 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 10 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =2.64 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 0 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 21.3 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 2.1 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 2.7 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 15.1 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 7.6 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 12 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 24 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 59.55 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 61.3 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 70.47 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 82.65 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
Showing 50 of 97 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cinnamyl alcohol | 203-212-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.001% (leave-on); 0.01% (rinse-off)
Category
fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 3-Phenyl-2-propen-1-ol?
3-Phenyl-2-propen-1-ol appears on 20 regulatory/inventory lists including Europe, inert_ingredient; non_food_use; Pesticides, Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener, and 17 more. Source: EPA CPDat.
Is 3-Phenyl-2-propen-1-ol used in cosmetics?
Yes, 3-Phenyl-2-propen-1-ol is also indexed as a cosmetic ingredient under the name Cinnamyl Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3-Phenyl-2-propen-1-ol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 3-Phenyl-2-propen-1-ol used outside industrial chemicals?
3-Phenyl-2-propen-1-ol also appears in cosmetics, food safety, cannabis databases.