Cinnamyl Alcohol
INCI: CINNAMYL ALCOHOL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Cinnamyl Alcohol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 53.5 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 6366 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 125 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Sensitization Profile
Contact sensitization data for Cinnamyl Alcohol based on clinical patch test studies and IFRA standards.
Source: ESSCA/IVDK
Dermal Penetration Profile
Skin absorption and penetration characteristics of Cinnamyl Alcohol, relevant to systemic exposure and MoS calculations.
Source: SCCS/1459/11, IFRA
Expert Verdict
FM I fragrance allergen functioning as a pro-hapten that oxidizes to cinnamaldehyde under use conditions, the primary sensitizing species. EU Annex III listed with mandatory labeling above 0.001% (leave-on) and 0.01% (rinse-off); IFRA restricts by product category.
Regulatory Flags
Frequently Asked Questions
Is Cinnamyl Alcohol safe in cosmetics?
FM I fragrance allergen functioning as a pro-hapten that oxidizes to cinnamaldehyde under use conditions, the primary sensitizing species. EU Annex III listed with mandatory labeling above 0.001% (leave-on) and 0.01% (rinse-off); IFRA restricts by product category. The EU classifies Cinnamyl Alcohol as "restricted". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database.
Is Cinnamyl Alcohol allowed in the EU?
Cinnamyl Alcohol EU regulatory status: restricted. Maximum allowed concentration: 0.001% (leave-on); 0.01% (rinse-off). This is based on EU Regulation 1223/2009 and its amendments.
What does Cinnamyl Alcohol do in cosmetics?
Cinnamyl Alcohol functions as: Fragrance ingredient. It is classified as a Fragrance in our database. CAS number: 104-54-1.
What is the Margin of Safety for Cinnamyl Alcohol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Cinnamyl Alcohol?
The NOAEL (No Observed Adverse Effect Level) for Cinnamyl Alcohol is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 6 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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