What is the NOAEL for 3-Phenylprop-2-enal?
3-Phenylprop-2-enal has 100 NOAEL studies in the database. The lowest reported value is 0.125 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3-Phenylprop-2-enal
Also known as: 2-07-00-00273, Acrolein, 3-phenyl-, BRN 0605737, Caswell No. 221A, Cinnamylaldehyde (+11 more)
CAS 104-55-2
3-Phenylprop-2-enal (CAS 104-55-2) is a chemical substance. Key regulatory status: REACH registered, 47 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Cinnamal (Cinnamaldehyde) →
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
47
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
3-Phenylprop-2-enal
CAS Number
104-55-2
DTXSID
DTXSID1024835
Molecular Formula
C9H8O
InChI Key
KJPRLNWUNMBNBZ-UHFFFAOYSA-N
Monoisotopic Mass
132.057515
Synonyms
2-07-00-00273Acrolein, 3-phenyl-BRN 0605737Caswell No. 221ACinnamylaldehydeCinnemaldehydeEINECS 203-213-9EPA Pesticide Chemical Code 040506FEMA No. 2286FEMA Number 2286NCI-C56111beta-Phenylcrolein
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceFlavouring and nutrientDeodorizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
47 records
| List | Keyword | Source |
|---|---|---|
| Cons electronics mech appliances and machinery; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - dental care - toothpaste | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; detected; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - fabric softener; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 12.3 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 14.5 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 14.7 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 15.7 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.5 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 1 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 7.5 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 10.2 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 10.3 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 18.8 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 8 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 12.7 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 28 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 31.1 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 38.3 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 54.9 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.125 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.2273 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.3125 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.41 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.625 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1.05 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1.25 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1.783 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2.675 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2.75 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.1818 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.2 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.25 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.3333 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.5 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.75 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 1 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| =2.204 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =6.11 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 67.1 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 70.6 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 77.5 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 43.2 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 50.3 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 64.7 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 56.9 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 58.7 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 71 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 4.38 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 5.84 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 6 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 6.27 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 6.5 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 6.54 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cinnamaldehyde | 203-213-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 3-Phenylprop-2-enal?
3-Phenylprop-2-enal appears on 30 regulatory/inventory lists including Cons electronics mech appliances and machinery; Europe, Europe, active_ingredient; Europe; Pesticides, and 27 more. Source: EPA CPDat.
Is 3-Phenylprop-2-enal used in cosmetics?
Yes, 3-Phenylprop-2-enal is also indexed as a cosmetic ingredient under the name Cinnamal (Cinnamaldehyde). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3-Phenylprop-2-enal come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 3-Phenylprop-2-enal used outside industrial chemicals?
3-Phenylprop-2-enal also appears in cosmetics, food safety, cannabis databases.