Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Cinnamal (Cinnamaldehyde). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 200 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 90 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 68 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1200 mg/kg bw/day | oral | mouse | Reproductive | COSMOS_DB |
| NOAEL | 25 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1.5 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 570 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 650 mg/kg bw/day | oral | mouse | Subchronic | COSMOS_DB |
Sensitization Profile
Contact sensitization data for Cinnamal (Cinnamaldehyde) based on clinical patch test studies and IFRA standards.
Source: ESSCA/IVDK
Expert Verdict
EU-listed fragrance allergen and strong sensitizer requiring declaration on label above threshold; can cause contact dermatitis with cross-reactivity to cinnamyl alcohol
Regulatory Flags
Frequently Asked Questions
Is Cinnamal (Cinnamaldehyde) safe in cosmetics?
EU-listed fragrance allergen and strong sensitizer requiring declaration on label above threshold; can cause contact dermatitis with cross-reactivity to cinnamyl alcohol The EU classifies Cinnamal (Cinnamaldehyde) as "restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Cinnamal (Cinnamaldehyde) allowed in the EU?
Cinnamal (Cinnamaldehyde) EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cinnamal (Cinnamaldehyde) do in cosmetics?
Cinnamal (Cinnamaldehyde) functions as: Denaturant, flavouring, fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 104-55-2.
What is the Margin of Safety for Cinnamal (Cinnamaldehyde)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Cinnamal (Cinnamaldehyde)?
The NOAEL (No Observed Adverse Effect Level) for Cinnamal (Cinnamaldehyde) is 200 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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