What is the NOAEL for Gamma-Nonanolactone?
Gamma-Nonanolactone has 18 NOAEL studies in the database. The lowest reported value is 16.1 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Gamma-Nonanolactone
Also known as: gamma-Nonanoic lactone, Dihydro-5-pentyl-2(3H)-furanone, Aldehyde C-18, gamma-Amyl-gamma-butyrolactone, delta-n-Amylbutyrolactone (+15 more)
CAS 104-61-0
Gamma-Nonanolactone (CAS 104-61-0) is a chemical substance. Key regulatory status: REACH registered, 25 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
18
SOURCE
chemical inventory jurisdictions
Regulatory lists
25
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Gamma-Nonanolactone
CAS Number
104-61-0
DTXSID
DTXSID0034229
Molecular Formula
C9H16O2
InChI Key
OALYTRUKMRCXNH-UHFFFAOYSA-N
Monoisotopic Mass
156.11503
Synonyms
gamma-Nonanoic lactoneDihydro-5-pentyl-2(3H)-furanoneAldehyde C-18gamma-Amyl-gamma-butyrolactonedelta-n-Amylbutyrolactonegamma-N-Amylbutyrolactone4-Amyl-4-hydroxybutyric acid lactoneCoconut aldehydeEINECS 203-219-1FEMA No. 2781FEMA Number 27814-Hydroxynonanoic acid, gamma-lactone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceDeodorizerSoftener and conditionerSolventFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
25 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Europe | European Commission | Fl@vis |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| detected; Toys and children's products | Springer Berlin Heidelberg | Published Articles |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =16.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| I1XGH66S8P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I1XGH66S8P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I1XGH66S8P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I1XGH66S8P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6480 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =6600 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =9780 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 61.4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >62.8 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >72.5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =112 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 18 of 18 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Nonan-4-olide | 203-219-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL191935
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 0-1.25 mg/kg bw (1967) mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Gamma-Nonanolactone?
Gamma-Nonanolactone appears on 8 regulatory/inventory lists including active_ingredient; Pesticides, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 5 more. Source: EPA CPDat.
Is Gamma-Nonanolactone used in cosmetics?
Yes, Gamma-Nonanolactone is also indexed as a cosmetic ingredient under the name gamma-Nonalactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Gamma-Nonanolactone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Gamma-Nonanolactone used outside industrial chemicals?
Gamma-Nonanolactone also appears in cosmetics, pharmaceutical, food safety, cannabis databases.