Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for gamma-Nonalactone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 61.4 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 61.4 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
No significant safety concerns. Used as RIFM read-across analog for multiple other ฮณ-lactones. Not genotoxic; not phototoxic.
Regulatory Flags
Frequently Asked Questions
Is gamma-Nonalactone safe in cosmetics?
No significant safety concerns. Used as RIFM read-across analog for multiple other ฮณ-lactones. Not genotoxic; not phototoxic. The EU classifies gamma-Nonalactone as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.
Is gamma-Nonalactone allowed in the EU?
gamma-Nonalactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does gamma-Nonalactone do in cosmetics?
gamma-Nonalactone functions as: Fragrance / masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 104-61-0.
What is the Margin of Safety for gamma-Nonalactone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for gamma-Nonalactone?
The NOAEL (No Observed Adverse Effect Level) for gamma-Nonalactone is 61.4 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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