NOAEL Data REACH Registered Cosmetic Ingredient

2-Ethyl-1-hexanol

Also known as: 2-Ethylhexanol, 1-Hexanol, 2-ethyl-, 4-01-00-01783, Alcohol, 2-ethylhexyl, BRN 1719280 (+5 more)

CAS 104-76-7

2-Ethyl-1-hexanol (CAS 104-76-7) is a chemical substance. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for 2-Ethylhexanol →

Cross-Vertical Regulatory Divergence

2-Ethyl-1-hexanol is classified GHS Danger (H315, H319, H332, H335, H227, H336, H361, H371) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields

Name

2-Ethyl-1-hexanol

CAS Number

104-76-7

DTXSID

DTXSID5020605

Molecular Formula

C8H18O

InChI Key

YIWUKEYIRIRTPP-UHFFFAOYSA-N

Monoisotopic Mass

130.135765

Synonyms

2-Ethylhexanol1-Hexanol, 2-ethyl-4-01-00-01783Alcohol, 2-ethylhexylBRN 1719280EINECS 203-234-3FEMA No. 31512-AethylhexanolUNII-XZV7TAA77PFEMA 3151

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Combustible liquid May be harmful if swallowed Causes skin and eye irritation May cause damage to central nervous system Harmful to aquatic life
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour, by ingestion and through the skin.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 26 records

SolventFragranceFlavouring and nutrientDegradant/impurityProcessing aids not otherwise specifiedDispersing agentPlasticizerDefoamerWetting agent (non-aqueous)No specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
fracking; water	NY Department of Conservation	CPCat
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
artificial_sweat; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
artificial_sweat; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - home office - pens and markers; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
CEDI	FDA	United States Food and Drug Administration (FDA)
artificial_saliva; detected; emissions; Europe; Furniture and Furnishings	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Other indirect contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; emissions; Europe; Other indirect contact consumer goods; water	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
<=0.5	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
=0.5	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
range:0-0.50.5	mg/kg bw/day	ADI	-	Rat	INCHEM_WHO_jecfa_jecmono_v32je04
=0.5	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
range:0-0.50.5	mg/kg bw/day	ADI	-	Rat	INCHEM_WHO_jecfa_jecmono_v32je04
=1.11	mg/m3	BMCL (HEC)	inhalation	Mouse	ToxValDB_PPRTV_(CPHEA)
=7.37	mg/kg bw/day	BMDL (05 HED)	oral	Rat	ToxValDB_PPRTV_(CPHEA)
=53.2	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
=12.8	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
51.3	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP_ICE_eye_irritation
XZV7TAA77P	UNII	FDA UNII substance identifier	-	-	openFDA substances
XZV7TAA77P	UNII	FDA UNII substance identifier	-	-	openFDA substances
XZV7TAA77P	UNII	FDA UNII substance identifier	-	-	openFDA substances
XZV7TAA77P	UNII	FDA UNII substance identifier	-	-	openFDA substances
2	unitless	GHS Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
2700	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
0.23	%/sec	Intensity	Ocular	-	NTP_ICE_eye_irritation
=2047	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=2053	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=3730	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=234.364	mg/m3	LEL	inhalation	Mouse	ToxValDB_ECHA_IUCLID
=46872.7	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=0.25	% diet	LOAEL	oral	Rat	ToxValDB_HPVIS
=0.46	% diet	LOAEL	oral	Rat	ToxValDB_HPVIS
>=0.66	% diet	LOAEL	oral	Mouse	ToxValDB_HPVIS
<=1.32	% diet	LOAEL	oral	Mouse	ToxValDB_HPVIS
150	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
250	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=250	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=330	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_HPVIS
500	mg/kg bw/day	LOAEL	oral	mouse	COSMOS_DB
<=500	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_HPVIS
<=1500	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_HPVIS
1525	mg/kg bw/day	LOAEL	oral	mouse	COSMOS_DB
=9.38	mmol/kg	LOEL	oral	Rat	ToxValDB_ECOTOX
840	mg/kg bw/day	LOEL	Dermal	Rat	NTP_ICE_dart
840	mg/kg bw/day	LOEL	Dermal	Rat	NTP_ICE_dart
840	mg/kg bw/day	LOEL	Dermal	Rat	NTP_ICE_dart
=1525	mg/kg bw/day	LOEL	oral	Mouse	ToxValDB_ECOTOX
2520	mg/kg bw/day	LOEL	Dermal	Rat	NTP_ICE_dart
-	s	Lag time	Ocular	-	NTP_ICE_eye_irritation
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=638.4	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=639.174	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
>=850	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=0.05	% diet	NOAEL	oral	Rat	ToxValDB_HPVIS
=0.32	mg/L	NOAEL	inhalation	Rat	ToxValDB_HPVIS
>=0.44	% diet	NOAEL	oral	Mouse	ToxValDB_HPVIS
=0.46	% diet	NOAEL	oral	Rat	ToxValDB_HPVIS

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-ethylhexan-1-ol	203-234-3	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL31637

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 0-0.5 mg/kg bw (1993) mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 2-Ethyl-1-hexanol?

2-Ethyl-1-hexanol has 100 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include 2-Ethyl-1-hexanol?

2-Ethyl-1-hexanol appears on 29 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, fracking; water, active_ingredient; Pesticides, and 26 more. Source: EPA CPDat.

Is 2-Ethyl-1-hexanol used in cosmetics?

Yes, 2-Ethyl-1-hexanol is also indexed as a cosmetic ingredient under the name 2-Ethylhexanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Ethyl-1-hexanol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Ethyl-1-hexanol have different safety status in cosmetics vs industrial chemicals?

2-Ethyl-1-hexanol is classified GHS Danger (H315, H319, H332, H335, H227, H336, H361, H371) in the chemicals database but is allowed in EU cosmetics.

Is 2-Ethyl-1-hexanol used outside industrial chemicals?

2-Ethyl-1-hexanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.