What is the NOAEL for HC Yellow 7?
HC Yellow 7 has 18 NOAEL studies in the database. The lowest reported value is 6L0860JBFE UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
HC Yellow 7
CAS 104226-21-3
HC Yellow 7 (CAS 104226-21-3) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
HC Yellow 7 is prohibited in EU cosmetics at max 0.25% but has active industrial GHS classifications (H301, H302, H335, H400, H410).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
18
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
6 fields
Name
HC Yellow 7
CAS Number
104226-21-3
DTXSID
DTXSID10879805
Molecular Formula
C17H22N4O2
InChI Key
YSVKKVUAUKQDBY-FMQUCBEESA-N
Monoisotopic Mass
314.174276
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 6L0860JBFE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6L0860JBFE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6L0860JBFE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6L0860JBFE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 10 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =25 | mg/kg bw/day | NOAEL | oral | - | SCCNFP_vision_codex |
| =25 | mg/kg bw/day | NOAEL | oral | - | SCCNFP_vision_codex |
| =25 | mg/kg bw/day | NOAEL | oral | - | SCCNFP_vision_codex |
| =25 | mg/kg bw/day | NOAEL | oral | - | SCCNFP_vision_codex |
| =80 | mg/kg bw/day | NOAEL | oral | - | SCCNFP_vision_codex |
| =80 | mg/kg bw/day | NOAEL | oral | - | SCCNFP_vision_codex |
| =80 | mg/kg bw/day | NOAEL | oral | - | SCCNFP_vision_codex |
| =80 | mg/kg bw/day | NOAEL | oral | - | SCCNFP_vision_codex |
| 25 | mg/kg bw/day | dermal absorption | - | human | UnifiedCodex:SCCNFP:beta.noael_studies |
| 25 | mg/kg bw/day | irritation | oral | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
| 25 | mg/kg bw/day | irritation | oral | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
| 25 | mg/kg bw/day | repeated dose toxicity | oral | - | UnifiedCodex:SCCNFP:beta.noael_studies |
| 80 | mg/kg bw/day | repeated dose toxicity | oral | - | UnifiedCodex:SCCNFP:beta.noael_studies |
Showing 18 of 18 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
0.25%
Category
Colorant
Frequently Asked Questions
What regulatory lists include HC Yellow 7?
HC Yellow 7 appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.
Is HC Yellow 7 used in cosmetics?
Yes, HC Yellow 7 is also indexed as a cosmetic ingredient under the name HC Yellow No. 7. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for HC Yellow 7 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does HC Yellow 7 have different safety status in cosmetics vs industrial chemicals?
HC Yellow 7 is prohibited in EU cosmetics at max 0.25% but has active industrial GHS classifications (H301, H302, H335, H400, H410).
Is HC Yellow 7 used outside industrial chemicals?
HC Yellow 7 also appears in cosmetics databases.