What is the GHS hazard classification for Ethyl propionate?
Ethyl propionate (CAS 105-37-3) is classified under EU CLP Annex VI as Flam. Liq. 2 with signal word Danger. Hazard statements: H225. Source: EU CLP Annex VI (ECHA).
Danger
GHS02
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ethyl propionate
Also known as: Propanoic acid, Ethyl ester, 4-02-00-00705, BRN 0506287, EINECS 203-291-4, FEMA No. 2456 (+7 more)
CAS 105-37-3
Ethyl propionate (CAS 105-37-3) is a chemical substance with GHS signal word Danger; key hazard signal: H225. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Ethyl propionate is classified GHS Danger (H225) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
8
SOURCE
Chemical inventory jurisdictions
Regulatory lists
6
SOURCE
EU CLP Annex VI
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Ethyl propionate
CAS Number
105-37-3
Molecular Formula
C5H10O2
InChI Key
FKRCODPIKNYEAC-UHFFFAOYSA-N
Monoisotopic Mass
102.06808
Synonyms
Propanoic acid, Ethyl ester4-02-00-00705BRN 0506287EINECS 203-291-4FEMA No. 2456Ethylester kyseliny propionoveUNII-AT9K8FY49UEthyl ester of propanoic acidEthyl n-propionateEthylpropionateFEMA 2456propionic acid ethyl ester
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2 | H225 | GHS02 | Danger |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
15 records
FragranceSolventFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =56 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| AT9K8FY49U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1350 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =8732 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =7.937e+4 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethyl propionate | 203-291-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ETHYL PROPIONATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Ethyl propionate?
Ethyl propionate has 8 NOAEL studies in the database. The lowest reported value is 56 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
What regulatory lists include Ethyl propionate?
Ethyl propionate appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Australia; Food and drug - smoking-related products, IFRA Transparency, and 3 more. Source: EPA CPDat.
Is Ethyl propionate used in cosmetics?
Yes, Ethyl propionate is also indexed as a cosmetic ingredient under the name Ethyl Propionate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethyl propionate come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Ethyl propionate have different safety status in cosmetics vs industrial chemicals?
Ethyl propionate is classified GHS Danger (H225) in the chemicals database but is allowed in EU cosmetics.
Is Ethyl propionate used outside industrial chemicals?
Ethyl propionate also appears in cosmetics, pharmaceutical, cannabis databases.