Moderate Cosmetic Ingredient NOAEL Data

Ethyl Propionate

CAS Number
105-37-3
Function
Flavouring and nutrient; Fragrance; Solvent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Ethyl Propionate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=1000 mg/kg bw/day oral - oral REACH
NOAEL >=1000 mg/kg bw/day oral - oral REACH

Expert Verdict

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Ethyl Propionate safe in cosmetics?

Ethyl Propionate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.

Is Ethyl Propionate allowed in the EU?

Ethyl Propionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethyl Propionate do in cosmetics?

Ethyl Propionate functions as: Flavouring and nutrient; Fragrance; Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 105-37-3.

What is the Margin of Safety for Ethyl Propionate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ethyl Propionate?

The NOAEL (No Observed Adverse Effect Level) for Ethyl Propionate is >=1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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