What is the NOAEL for Diethyl propanedioate?
Diethyl propanedioate has 12 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diethyl propanedioate
Also known as: propanedioic acid, diethyl ester, Diethyl malonate, EINECS 203-305-9, Ethyl malonate, Ethyl methanedicarboxylate (+5 more)
CAS 105-53-3
Diethyl propanedioate (CAS 105-53-3) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
12
SOURCE
Chemical inventory jurisdictions
Regulatory lists
6
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Diethyl propanedioate
CAS Number
105-53-3
Molecular Formula
C7H12O4
InChI Key
IYXGSMUGOJNHAZ-UHFFFAOYSA-N
Monoisotopic Mass
160.073559
Synonyms
propanedioic acid, diethyl esterDiethyl malonateEINECS 203-305-9Ethyl malonateEthyl methanedicarboxylateEthyl propanedioateFEMA No. 2375Malonic esterMethanedicarboxylic acid, diethyl esterUNII-53A58PA183
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Combustible liquid Causes eye irritation Harmful to aquatic life |
| Short-term Effects | The substance is mildly irritating to the eyes. |
| Long-term Effects | Health effects of the substance have been investigated but none have been found |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 63.27 | uM | AC50 | - | - | NTP ICE endocrine |
| 58.18 | uM | ACC | - | - | NTP ICE endocrine |
| =8.468 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 53A58PA183 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 2.000e+4 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.00416 | unitless | Model Score | - | - | NTP ICE endocrine |
| 36 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diethyl malonate | 203-305-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
MALONIC ACID DIETHYL ESTER
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Diethyl propanedioate?
Diethyl propanedioate appears on 6 regulatory/inventory lists including Australia; Food and drug - smoking-related products, IFRA Transparency, Europe, and 3 more. Source: EPA CPDat.
Is Diethyl propanedioate used in cosmetics?
Yes, Diethyl propanedioate is also indexed as a cosmetic ingredient under the name Diethyl Malonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diethyl propanedioate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Diethyl propanedioate used outside industrial chemicals?
Diethyl propanedioate also appears in cosmetics, pharmaceutical, cannabis databases.