Diethyl Malonate
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Diethyl Malonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 36 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 36 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Diethyl malonate is a fragrance ingredient permitted for use in cosmetics with low safety concern and established low absorption and sensitization profiles.
Regulatory Flags
Frequently Asked Questions
Is Diethyl Malonate safe in cosmetics?
Diethyl malonate is a fragrance ingredient permitted for use in cosmetics with low safety concern and established low absorption and sensitization profiles. The EU classifies Diethyl Malonate as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.
Is Diethyl Malonate allowed in the EU?
Diethyl Malonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethyl Malonate do in cosmetics?
Diethyl Malonate functions as: Flavouring and nutrient; Fragrance; No specific technical function. It is classified as a cosmetic ingredient in our database. CAS number: 105-53-3.
What is the Margin of Safety for Diethyl Malonate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diethyl Malonate?
The NOAEL (No Observed Adverse Effect Level) for Diethyl Malonate is 36 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Is Diethyl Malonate classified as hazardous under GHS?
Diethyl Malonate carries a GHS signal word of "WARNING". Hazard statements: Combustible liquid Causes eye irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
Check Diethyl Malonate compliance across multiple jurisdictions:
Related Ingredients
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