Also known as: 2H-Azepin-2-one, hexahydro-, 5-21-06-00444, 6-Aminocaproic acid lactam, 6-Aminohexanoic acid cyclic lactam, 2H-Azepin-7-one, hexahydro- (+15 more)
CAS 105-60-2
Caprolactam (CAS 105-60-2) is a chemical substance with GHS signal word Warning; key hazard signal: H332; H302; H335; H315; H319. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 39, Sup 7, 71 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2 | H332; H302; H335; H315; H319 | GHS07 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Harmful if swallowed Causes skin and eye irritation May cause drowsiness or dizziness |
| Short-term Effects | The substance is irritating to the skin, eyes and respiratory tract. The substance may cause effects on the central nervous system. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the nervous system and liver. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 1 mg/m³ (dust), 0.22 ppm (1 mg/m³) (vapor) | 0.22 | 1 | N |
| ACGIH | TWA | 5 mg/m³ (inhalable fraction and vapor) [1997] | - | 5 | N |
| CAL/OSHA | TWA | 1 mg/m³ [dust], 5 ppm (20 mg/m³) [vapor] | 5 | 1 | N |
| CAL/OSHA | STEL | 3 mg/m³ [dust], 10 ppm (40 mg/m³) [vapor] | 10 | 3 | N |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| Cons electronics mech appliances and machinery; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =3 | mg/m3 | BMCL (05) | inhalation | Rat | ToxValDB_Cal_OEHHA_REL_derivations |
| - | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| - | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| =5 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 6879X594Z8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6879X594Z8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6879X594Z8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6879X594Z8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.761 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 0.3 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =31 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =31 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =125 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =125 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =188 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =188 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =750 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =750 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1125 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =1125 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =47 | mg/m3 | LOAEL | inhalation | Human | ToxValDB_EU_SCOEL |
| =250 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_IRIS |
| =425 | ppm | LOEL | oral | Rat | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >- | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =63 | mg/kg bw/day | NEL | oral | Rat | ToxValDB_ToxRefDB |
| =63 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =0.5 | mg/m3 | NOAEL | inhalation | Human | ToxValDB_Cal_OEHHA_REL_derivations |
| =33 | mg/m3 | NOAEL | inhalation | Human | ToxValDB_EU_SCOEL |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_IRIS |
| =50 | mg/kg/day | NOAEL | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| =500 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECOTOX |
| =700 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =750 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_EFSA |
| =750 | mg/kg bw/day | NOEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =750 | mg/kg bw/day | NOEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =0.0022 | mg/m3 | RfC | inhalation | Human | ToxValDB_RSL |
| =0.5 | mg/kg bw/day | RfD | oral | Human | ToxValDB_IRIS |
| =0.5 | mg/kg/day | RfD | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| 7500 | ppm | Top dose | Dosed feed | Rat | NTP_ICE_cancer |
| 15000 | ppm | Top dose | Dosed feed | Mouse | NTP_ICE_cancer |
Showing 45 of 45 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | ε-caprolactam | 203-313-2 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Caprolactam (CAS 105-60-2) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2 with signal word Warning. Hazard statements: H332; H302; H335; H315; H319. Source: EU CLP Annex VI (ECHA).
Caprolactam has 45 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
Caprolactam appears on 7 regulatory/inventory lists including Europe, drinking_water; Europe; manufacturing; plastic_additive, Cons electronics mech appliances and machinery; Europe, and 4 more. Source: EPA CPDat.
Caprolactam is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Occupational exposure limits for Caprolactam are set by NIOSH, ACGIH, CAL/OSHA. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Caprolactam is also indexed as a cosmetic ingredient under the name Caprolactam. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Caprolactam also appears in cosmetics, pharmaceutical, cannabis databases.