What is the NOAEL for Dibutyl adipate?
Dibutyl adipate has 7 NOAEL studies in the database. The lowest reported value is 14.03 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dibutyl adipate
Also known as: Adimoll DB, Hexanedioic acid, 1,6-dibutyl ester, Adipic acid, dibutyl ester, Monocizer W 260, Adipic acid di-n-butyl ester (+14 more)
CAS 105-99-7
Dibutyl adipate (CAS 105-99-7) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Dibutyl adipate is classified GHS CMR hazard (H411, H361, H401) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Dibutyl adipate
CAS Number
105-99-7
DTXSID
DTXSID2021866
Molecular Formula
C14H26O4
InChI Key
XTJFFFGAUHQWII-UHFFFAOYSA-N
Monoisotopic Mass
258.183109
Synonyms
Adimoll DBHexanedioic acid, 1,6-dibutyl esterAdipic acid, dibutyl esterMonocizer W 260Adipic acid di-n-butyl esterDibutyl hexanedioateBRN 1790739Butyl adipateCetiol BEINECS 203-350-4Experimental tick repellent 3Experimental tick repellent 3PS
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Causes mild skin irritation Toxic to aquatic life |
| Short-term Effects | The substance is mildly irritating to the skin. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
20 records
SolventSoftener and conditionerFilm formerPlasticizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 14.03 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| F4K100DXP3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| F4K100DXP3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| F4K100DXP3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| F4K100DXP3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.5872 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dibutyl adipate | 203-350-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3188143
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Dibutyl adipate?
Dibutyl adipate appears on 1 regulatory/inventory list including Europe; plastic_additive. Source: EPA CPDat.
Is Dibutyl adipate used in cosmetics?
Yes, Dibutyl adipate is also indexed as a cosmetic ingredient under the name Dibutyl Adipate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dibutyl adipate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Dibutyl adipate have different safety status in cosmetics vs industrial chemicals?
Dibutyl adipate is classified GHS CMR hazard (H411, H361, H401) in the chemicals database but is allowed in EU cosmetics.
Is Dibutyl adipate used outside industrial chemicals?
Dibutyl adipate also appears in cosmetics, pharmaceutical databases.