Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Dibutyl Adipate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 630 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 2 other | dermal | code:3532 | dermal | REACH |
| LOAEL | 0.5 other | dermal | code:3484 | dermal | REACH |
| NOAEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 178 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 200 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 630 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | 200 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | 178 mg/kg bw/day | oral | - | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
No comedogenicity in clinical testing; no genotoxicity; equivocal in vitro phototoxicity result but negative in clinical photo testing; commonly used at ≤5% in nail products and ≤8% in suncare.
Regulatory Flags
Frequently Asked Questions
Is Dibutyl Adipate safe in cosmetics?
No comedogenicity in clinical testing; no genotoxicity; equivocal in vitro phototoxicity result but negative in clinical photo testing; commonly used at ≤5% in nail products and ≤8% in suncare. The EU classifies Dibutyl Adipate as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Dibutyl Adipate allowed in the EU?
Dibutyl Adipate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dibutyl Adipate do in cosmetics?
Dibutyl Adipate functions as: Emollient, film forming, plasticizer, skin conditioning, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 105-99-7.
What is the Margin of Safety for Dibutyl Adipate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dibutyl Adipate?
The NOAEL (No Observed Adverse Effect Level) for Dibutyl Adipate is 630 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Is Dibutyl Adipate classified as hazardous under GHS?
Dibutyl Adipate carries a GHS signal word of "WARNING". Hazard statements: Causes mild skin irritation Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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