NOAEL Data REACH Registered Cosmetic Ingredient

(Z)-Nerol

Also known as: (Z)-3,7-Dimethyl-2,6-octadienol, Nerol 900, cis-1-Hydroxy-3,7-dimethyl-2,6-octadiene, (2Z)-3,7-dimethylocta-2,6-dien-1-ol, UN 1993 (+15 more)

CAS 106-25-2

(Z)-Nerol (CAS 106-25-2) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for NEROL →

Cross-Vertical Regulatory Divergence

(Z)-Nerol is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

(Z)-Nerol

CAS Number

106-25-2

DTXSID

DTXSID3026728

Molecular Formula

C10H18O

InChI Key

GLZPCOQZEFWAFX-YFHOEESVSA-N

Monoisotopic Mass

154.135765

Synonyms

(Z)-3,7-Dimethyl-2,6-octadienolNerol 900cis-1-Hydroxy-3,7-dimethyl-2,6-octadiene(2Z)-3,7-dimethylocta-2,6-dien-1-olUN 19932,6-Octadien-1-ol, 3,7-dimetil-, (2Z) -3,7-Dimethyl-2,6-octadien-1-ol, cis-3,7-Dimethyl-2,6-octadien-1-ol, (Z)-EINECS 203-378-7FEMA No. 2770NSC-46105UNII-38G5P53250

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
detected; Europe; Personal care - sexual wellness	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - sexual wellness	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 15 of 15 studies

Value	Unit	Endpoint	Route	Species	Source
1.57	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=4.4	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
38G5P53250	UNII	FDA UNII substance identifier	-	-	openFDA substances
38G5P53250	UNII	FDA UNII substance identifier	-	-	openFDA substances
38G5P53250	UNII	FDA UNII substance identifier	-	-	openFDA substances
38G5P53250	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	fraction	Fu	-	Human	NTP_ICE_adme_parameters
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
2592	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
=4500	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=345	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=345	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=345	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 15 of 15 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Nerol	203-378-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL NEROL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for (Z)-Nerol?

(Z)-Nerol has 15 NOAEL studies in the database. The lowest reported value is 1.57 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include (Z)-Nerol?

(Z)-Nerol appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, detected; Europe; Personal care - sexual wellness, air; detected; emissions; Europe; Vehicle - car interior, and 3 more. Source: EPA CPDat.

Is (Z)-Nerol used in cosmetics?

Yes, (Z)-Nerol is also indexed as a cosmetic ingredient under the name NEROL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for (Z)-Nerol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does (Z)-Nerol have different safety status in cosmetics vs industrial chemicals?

(Z)-Nerol is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.

Is (Z)-Nerol used outside industrial chemicals?

(Z)-Nerol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.