Is NEROL safe in cosmetics?
NEROL has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed.
Good
Cosmetic Ingredient
NEROL
Also known as: (Z)-3,7-Dimethyl-2,6-octadienol, Nerol 900, cis-1-Hydroxy-3,7-dimethyl-2,6-octadiene, (2Z)-3,7-dimethylocta-2,6-dien-1-ol, UN 1993 (+15 more)
NEROL (CAS 106-25-2) is a cosmetic cosmetic ingredient functioning as Perfuming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 106-25-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
NEROL is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
(2Z)-3,7-dimethylocta-2,6-dien-1-ol
InChIKey
GLZPCOQZEFWAFX-YFHOEESVSA-N
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
Allowed — also holds GRAS status (Generally Recognized As Safe) for flavor use under FDA/FEMA evaluations.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Skin Eye Respiratory Irritation
Nerol resulted in moderate skin irritation. | Skin irritation: Nerol applied full strength to intact or abraded rabbit skin for 24 hours produced moderate irritation. | A skin irritant.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (4)
JECFA Number
1224
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
NEROL | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/75 | FAS 52-JECFA 61/289
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
(Z)-GERANIOL | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/75 | FAS 52-JECFA 61/289
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
(Z)-NEROL | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/75 | FAS 52-JECFA 61/289
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for NEROL.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to NEROL by CAS number or substance name.
Studies
3
Lowest NOAEL
750 mg/kg bw/day
Highest NOAEL
750 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
(Z)-3,7-Dimethyl-2,6-octadienol
Nerol 900
cis-1-Hydroxy-3,7-dimethyl-2,6-octadiene
(2Z)-3,7-dimethylocta-2,6-dien-1-ol
UN 1993
2,6-Octadien-1-ol, 3,7-dimetil-, (2Z) -
3,7-Dimethyl-2,6-octadien-1-ol, cis-
3,7-Dimethyl-2,6-octadien-1-ol, (Z)-
EINECS 203-378-7
FEMA No. 2770
NSC-46105
UNII-38G5P53250
(2E)3,7-dimethyl-2,6-Octadien-1-ol
(E)3,7-Dimethyl-Octadien-1-ol
(E)3,7-dimethyl-2,6-Octadien-1-ol
(Z)-3,7-Dimethylocta-2,6-dien-1-ol
(Z)-3,7-dimethyl-2,6-octadien-1-ol
(Z)3,7-dimethyl-2,6-Octadien-1-ol
(cis)3,7-dimethyl-2,6-Octadien-1-ol
2,6-Dimethyl-trans-2,6-octadien-8-ol
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - sexual wellness
air; detected; emissions; Europe; Vehicle - car interior
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NEROL
ChEMBL ID
CHEMBL452683
Frequently Asked Questions
Is NEROL allowed in the EU?
NEROL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NEROL do in cosmetics?
NEROL functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 106-25-2.
Is NEROL used outside cosmetics?
NEROL also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does NEROL have different safety status in cosmetics vs industrial chemicals?
NEROL is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check NEROL compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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