What is the NOAEL for Ethyl octanoate?
Ethyl octanoate has 11 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ethyl octanoate
Also known as: Ethyl n-octanoate, Caprylic acid ethyl ester, BRN 1754470, EINECS 203-385-5, Ethyl octoate (+3 more)
CAS 106-32-1
Ethyl octanoate (CAS 106-32-1) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
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NOAEL studies
NOAEL studies
11
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Chemical inventory jurisdictions
Regulatory lists
4
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EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
13 fields
Name
Ethyl octanoate
CAS Number
106-32-1
Molecular Formula
C10H20O2
InChI Key
YYZUSRORWSJGET-UHFFFAOYSA-N
Monoisotopic Mass
172.14633
Synonyms
Ethyl n-octanoateCaprylic acid ethyl esterBRN 1754470EINECS 203-385-5Ethyl octoateEthyl octylateFEMA No. 2449UNII-81C5MOP582
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
17 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1.25 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 81C5MOP582 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 8 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1350 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 843.8 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 675 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =2.596e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethyl octanoate | 203-385-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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ChEMBL / DailyMed
CHEMBL4633100
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ethyl octanoate?
Ethyl octanoate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Ethyl octanoate used in cosmetics?
Yes, Ethyl octanoate is also indexed as a cosmetic ingredient under the name Ethyl Octanoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethyl octanoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Ethyl octanoate used outside industrial chemicals?
Ethyl octanoate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.