Good Cosmetic Ingredient NOAEL Data

Ethyl Octanoate

INCI: ETHYL OCTANOATE

CAS Number
106-32-1
Function
Fragrance, solvent
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” GRAS as a flavor substance (21 CFR 182.60); no cosmetic-specific restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

9 study endpoints found for Ethyl Octanoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL >=1000 mg/kg bw/day oral rat oral REACH
NOAEL >=1194.3 mg/kg bw/day oral - oral REACH
NOAEL >10000 ppm oral rat oral REACH
NOAEL >10000 ppm oral rat oral REACH
NOAEL >10000 ppm oral rat oral REACH
NOAEL >10000 ppm oral - oral REACH
NOAEL >10000 ppm oral - oral REACH

Expert Verdict

Volatile fragrance ingredient contributing to top-notes; flammable liquid requiring inhalation exposure evaluation in spray products per SCCS aerosol guidance.

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Ethyl Octanoate safe in cosmetics?

Volatile fragrance ingredient contributing to top-notes; flammable liquid requiring inhalation exposure evaluation in spray products per SCCS aerosol guidance. The EU classifies Ethyl Octanoate as "permitted". Safety rating: GOOD. 9 toxicological study endpoint(s) are available in our database.

Is Ethyl Octanoate allowed in the EU?

Ethyl Octanoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethyl Octanoate do in cosmetics?

Ethyl Octanoate functions as: Fragrance, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 106-32-1.

What is the Margin of Safety for Ethyl Octanoate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ethyl Octanoate?

The NOAEL (No Observed Adverse Effect Level) for Ethyl Octanoate is 1000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 9 study endpoints are available. Source: COSMOS_DB.

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