Is Ethyl Octanoate safe in cosmetics?
Ethyl Octanoate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Ethyl Octanoate
Also known as: Ethyl n-octanoate, Caprylic acid ethyl ester, BRN 1754470, EINECS 203-385-5, Ethyl octoate (+3 more)
INCI: ETHYL OCTANOATE
Ethyl Octanoate (CAS 106-32-1) is a cosmetic cosmetic ingredient functioning as Fragrance, solvent. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 106-32-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance, solvent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
ethyl octanoate
InChIKey
YYZUSRORWSJGET-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — GRAS as a flavor substance (21 CFR 182.60); no cosmetic-specific restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Octanoate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethyl Octanoate across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
1350 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [193] Kligman AM (1975): Reports to RIFM, 24 October & 10 December, unpublished.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1350 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
33
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ETHYL OCTANOATE | 1996 | No safety concern at current levels of intake when used as a flavouring agent | TRS 868-JECFA 46/21 | See TRS 868-JECFA 46/64
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Octanoate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Ethyl n-octanoate
Caprylic acid ethyl ester
BRN 1754470
EINECS 203-385-5
Ethyl octoate
Ethyl octylate
FEMA No. 2449
UNII-81C5MOP582
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL4633100
Frequently Asked Questions
Is Ethyl Octanoate allowed in the EU?
Ethyl Octanoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Octanoate do in cosmetics?
Ethyl Octanoate functions as: Fragrance, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 106-32-1.
Is Ethyl Octanoate used outside cosmetics?
Ethyl Octanoate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethyl Octanoate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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