NOAEL Data REACH Registered Cosmetic Ingredient

C.I. Acid Black 1, disodium salt

Also known as: Naphthol Blue Black, C.I. Acid Black 1, 2,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-3-[2-(4-nitrophenyl)diazenyl]-6-(2-phenyldiazenyl)-, sodium salt (1:2), D and C Black No. 1, D And C Black Number 1 (+15 more)

CAS 1064-48-8

C.I. Acid Black 1, disodium salt (CAS 1064-48-8) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for CI 20470 →

Cross-Vertical Regulatory Divergence

C.I. Acid Black 1, disodium salt is classified GHS Danger (H315, H317, H319, H335, H372) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

C.I. Acid Black 1, disodium salt

CAS Number

1064-48-8

DTXSID

DTXSID1024415

Molecular Formula

C22H16N6O9S2.2Na

InChI Key

AOMZHDJXSYHPKS-UHFFFAOYSA-L

Monoisotopic Mass

618.021557

Synonyms

Naphthol Blue BlackC.I. Acid Black 12,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-3-[2-(4-nitrophenyl)diazenyl]-6-(2-phenyldiazenyl)-, sodium salt (1:2)D and C Black No. 1D And C Black Number 1D&C Black 1Acid Black HAcid Black 1Acid Black 10AAcid Black 10BAcid Black 10BAAcid Black 10BN

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Europe; Personal care	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 31 of 31 studies

Value	Unit	Endpoint	Route	Species	Source
1	-	-	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
5	mg/kg/day	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
SZT789770M	UNII	FDA UNII substance identifier	-	-	openFDA substances
SZT789770M	UNII	FDA UNII substance identifier	-	-	openFDA substances
SZT789770M	UNII	FDA UNII substance identifier	-	-	openFDA substances
SZT789770M	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.300000011921	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=0.5	%	NOAEL	oral	mouse	SCCS_vision_codex
=0.5	%	NOAEL	oral	mouse	SCCS_vision_codex
=0.5	%	NOAEL	oral	mouse	SCCS_vision_codex
=0.5	%	NOAEL	oral	mouse	SCCS_vision_codex
=0.78	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.78	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.78	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.78	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=1	-	NOAEL	-	rat	SCCS_vision_codex
=1	-	NOAEL	-	rat	SCCS_vision_codex
=1	-	NOAEL	-	rat	SCCS_vision_codex
=1	-	NOAEL	-	rat	SCCS_vision_codex
=5	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=5	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=5	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=5	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=40	mg/kg bw/day	NOAEL	-	human	SCCS_vision_codex
=40	mg/kg bw/day	NOAEL	-	human	SCCS_vision_codex
=40	mg/kg bw/day	NOAEL	-	human	SCCS_vision_codex
=40	mg/kg bw/day	NOAEL	-	human	SCCS_vision_codex
0.5	%	dermal absorption	oral	mouse	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=0.78	mg/kg bw/d	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
40	mg/kg bw/day	developmental toxicity	-	human	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
40	mg/kg bw/day	repeated dose toxicity	dermal	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 31 of 31 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Sodium 4-amino-5-hydroxy-3-(4-nitrophenylazo)-6-(phenylazo)naphthalene-2,7-disulphonate	213-903-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1492/12	12 December 2013	not safe	-	low margin of safety; moderate sensitiser

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Frequently Asked Questions

What is the NOAEL for C.I. Acid Black 1, disodium salt?

C.I. Acid Black 1, disodium salt has 31 NOAEL studies in the database. The lowest reported value is 1 mg/kg bw/day in rat. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include C.I. Acid Black 1, disodium salt?

C.I. Acid Black 1, disodium salt appears on 4 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring, inert_ingredient; non_food_use; Pesticides, and 1 more. Source: EPA CPDat.

Is C.I. Acid Black 1, disodium salt used in cosmetics?

Yes, C.I. Acid Black 1, disodium salt is also indexed as a cosmetic ingredient under the name CI 20470. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for C.I. Acid Black 1, disodium salt come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does C.I. Acid Black 1, disodium salt have different safety status in cosmetics vs industrial chemicals?

C.I. Acid Black 1, disodium salt is classified GHS Danger (H315, H317, H319, H335, H372) in the chemicals database but is allowed in EU cosmetics.

Is C.I. Acid Black 1, disodium salt used outside industrial chemicals?

C.I. Acid Black 1, disodium salt also appears in cosmetics databases.