What is the NOAEL for C.I. Acid Black 1, disodium salt?
C.I. Acid Black 1, disodium salt has 13 NOAEL studies in the database. The lowest reported value is 0.3 mg/kg bw/day via oral in rat. Source: COSMOS DB.
NOAEL Data
REACH Registered
Cosmetic Ingredient
C.I. Acid Black 1, disodium salt
Also known as: Naphthol Blue Black, C.I. Acid Black 1, 2,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-3-[2-(4-nitrophenyl)diazenyl]-6-(2-phenyldiazenyl)-, sodium salt (1:2), D and C Black No. 1, D And C Black Number 1 (+15 more)
CAS 1064-48-8
C.I. Acid Black 1, disodium salt (CAS 1064-48-8) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Cross-Vertical Regulatory Divergence
C.I. Acid Black 1, disodium salt is classified GHS Danger (H315, H317, H319, H335, H372) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
13
SOURCE
Chemical inventory jurisdictions
Regulatory lists
6
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
C.I. Acid Black 1, disodium salt
CAS Number
1064-48-8
Molecular Formula
C22H16N6O9S2.2Na
InChI Key
AOMZHDJXSYHPKS-UHFFFAOYSA-L
Monoisotopic Mass
618.021557
Synonyms
Naphthol Blue BlackC.I. Acid Black 12,7-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-3-[2-(4-nitrophenyl)diazenyl]-6-(2-phenyldiazenyl)-, sodium salt (1:2)D and C Black No. 1D And C Black Number 1D&C Black 1Acid Black HAcid Black 1Acid Black 10AAcid Black 10BAcid Black 10BAAcid Black 10BN
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1 | - | - | - | rat | Regulatory source |
| 5 | mg/kg/day | - | - | - | Regulatory source |
| SZT789770M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.3 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =0.5 | % | NOAEL | oral | mouse | SCCS Opinion |
| =0.78 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =1 | - | NOAEL | - | rat | SCCS Opinion |
| =5 | mg/kg/day | NOAEL | - | - | SCCS Opinion |
| =40 | mg/kg bw/day | NOAEL | - | human | SCCS Opinion |
| 0.5 | % | dermal absorption | oral | mouse | Regulatory source |
| =0.78 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| 40 | mg/kg bw/day | developmental toxicity | - | human | Regulatory source |
| 40 | mg/kg bw/day | repeated dose toxicity | dermal | rat | Regulatory source |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium 4-amino-5-hydroxy-3-(4-nitrophenylazo)-6-(phenylazo)naphthalene-2,7-disulphonate | 213-903-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1492/12 | 12 December 2013 | not safe | - | low margin of safety; moderate sensitiser |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorants
Frequently Asked Questions
What regulatory lists include C.I. Acid Black 1, disodium salt?
C.I. Acid Black 1, disodium salt appears on 4 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring, inert_ingredient; non_food_use; Pesticides, and 1 more. Source: EPA CPDat.
Is C.I. Acid Black 1, disodium salt used in cosmetics?
Yes, C.I. Acid Black 1, disodium salt is also indexed as a cosmetic ingredient under the name CI 20470. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for C.I. Acid Black 1, disodium salt come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does C.I. Acid Black 1, disodium salt have different safety status in cosmetics vs industrial chemicals?
C.I. Acid Black 1, disodium salt is classified GHS Danger (H315, H317, H319, H335, H372) in the chemicals database but is allowed in EU cosmetics.
Is C.I. Acid Black 1, disodium salt used outside industrial chemicals?
C.I. Acid Black 1, disodium salt also appears in cosmetics databases.