Moderate Cosmetic Ingredient NOAEL Data

CI 20470

CAS Number
1064-48-8
Function
Colorant
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not listed as FDA-approved color additive for cosmetics; not in 21 CFR Part 74 or 82; use restricted in US

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for CI 20470. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 0.300000011921 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

CI 20470 (Acid Black 1, Naphthol Blue Black) is permitted in EU Annex IV for rinse-off cosmetics only; not approved by FDA for US cosmetics; moderate concern due to azo chemistry and potential amine metabolites; low skin contact time in rinse-off limits risk.

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Concern Level: Moderate

Regulatory Flags

azo-dye rinse-off-only eu-annex-iv not-fda-approved aromatic-amine-concern eu_cosing_listed

Frequently Asked Questions

Is CI 20470 safe in cosmetics?

CI 20470 (Acid Black 1, Naphthol Blue Black) is permitted in EU Annex IV for rinse-off cosmetics only; not approved by FDA for US cosmetics; moderate concern due to azo chemistry and potential amine metabolites; low skin contact time in rinse-off limits risk. The EU classifies CI 20470 as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is CI 20470 allowed in the EU?

CI 20470 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CI 20470 do in cosmetics?

CI 20470 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 1064-48-8.

What is the Margin of Safety for CI 20470?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for CI 20470?

The NOAEL (No Observed Adverse Effect Level) for CI 20470 is 0.300000011921 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

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