Warning GHS08GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Glyoxal

Also known as: Ethanedial, 4-01-00-03625, Aerotex glyoxal 40, BRN 1732463, EINECS 203-474-9 (+4 more)

CAS 107-22-2

Glyoxal (CAS 107-22-2) is a chemical substance with GHS signal word Warning; key hazard signal: H341; H332; H315; H319; H317. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Glyoxal →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
5
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 15 fields
Name
Glyoxal
CAS Number
107-22-2
DTXSID
DTXSID5025364
Molecular Formula
C2H2O2
InChI Key
LEQAOMBKQFMDFZ-UHFFFAOYSA-N
Monoisotopic Mass
58.005479
Synonyms
Ethanedial4-01-00-03625Aerotex glyoxal 40BRN 1732463EINECS 203-474-9UNII-50NP6JJ975Diformalethane-1,2-dialoxal

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Muta. 2; Acute Tox. 4 *; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1H341; H332; H315; H319; H317GHS08; GHS07Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe substance is irritating to the eyes and skin.
Long-term EffectsRepeated or prolonged contact may cause skin sensitization.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its aerosol or vapour and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 2 records
AgencyMetricValueppmmg/m3Skin
ACGIHTWA0.1 mg/m³ (inhalable fraction and vapor) [1999]-0.1N
CAL/OSHATWA0.1 mg/m³-0.1N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 9 records
FragranceBiocidePreservativeChemical reaction regulatorFilm former

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records
ListKeywordSource
inert_ingredient; non_food_use; PesticidesEPACPCat
active_ingredient; Europe; PesticidesEuropean CommissionCPCat
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
0.4--inhalationratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
5mg/kg bw-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
24----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
24--inhalationratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
40mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
40%--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
40mg/kg bw/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
100mg/kg bw/day---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
100mg/kg bw-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
100mg/kg bw-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
100mg/kg bw-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
107mg/kg bw---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
107mg/kg bw-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
115mg/kg bw-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
115mg/kg bw-oraldogUnifiedCodex:SCCS_SHADOW:beta.noael_studies
132mg/kg bw-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
286.7ug/mLCD54, EC200Dermal-NTP_ICE_skin_sensitization
27.998ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
32.63ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
92.79ug/mLCV70Dermal-NTP_ICE_skin_sensitization
396ug/mLCV75Dermal-NTP_ICE_skin_sensitization
0.5%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
0.4167%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
=0.04mg/m3DNEL localinhalationHumanToxValDB_GESTIS_DNEL
=2.96mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
56.5%Depletion CysDermal-NTP_ICE_skin_sensitization
68.2%Depletion CysDermal-NTP_ICE_skin_sensitization
26.7%Depletion LysDermal-NTP_ICE_skin_sensitization
67.8%Depletion LysDermal-NTP_ICE_skin_sensitization
47%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
62.15%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
24.58uMEC1.5Dermal-NTP_ICE_skin_sensitization
77uMEC1.5Dermal-NTP_ICE_skin_sensitization
80.41uMEC1.5Dermal-NTP_ICE_skin_sensitization
87uMEC1.5Dermal-NTP_ICE_skin_sensitization
88.6uMEC1.5Dermal-NTP_ICE_skin_sensitization
89.1uMEC1.5Dermal-NTP_ICE_skin_sensitization
89.12uMEC1.5Dermal-NTP_ICE_skin_sensitization
91.7uMEC1.5Dermal-NTP_ICE_skin_sensitization
95.6uMEC1.5Dermal-NTP_ICE_skin_sensitization
100.92uMEC1.5Dermal-NTP_ICE_skin_sensitization
107.53uMEC1.5Dermal-NTP_ICE_skin_sensitization
115.89uMEC1.5Dermal-NTP_ICE_skin_sensitization
116.87uMEC1.5Dermal-NTP_ICE_skin_sensitization
120uMEC1.5Dermal-NTP_ICE_skin_sensitization
123.92uMEC1.5Dermal-NTP_ICE_skin_sensitization
127.41uMEC1.5Dermal-NTP_ICE_skin_sensitization
127.64uMEC1.5Dermal-NTP_ICE_skin_sensitization
130.5uMEC1.5Dermal-NTP_ICE_skin_sensitization
131.2uMEC1.5Dermal-NTP_ICE_skin_sensitization

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registeredglyoxal … %; ethandial … %203-474-9ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/0876/0521 June 2005not safeNot safe in cosmeticsPotential genotoxin/mutagen; skin sensitiser; cross-links proteins; not suitable for cosmetic use

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
0.05%
Category
Preservative
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1606435
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Glyoxal?

Glyoxal (CAS 107-22-2) is classified under EU CLP Annex VI as Muta. 2; Acute Tox. 4 *; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1 with signal word Warning. Hazard statements: H341; H332; H315; H319; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Glyoxal?

Glyoxal has 100 NOAEL studies in the database. The lowest reported value is 0.04 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Glyoxal?

Glyoxal appears on 4 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides, Indirect additives food contact (10/2018), and 1 more. Source: EPA CPDat.

What are the occupational exposure limits for Glyoxal?

Occupational exposure limits for Glyoxal are set by ACGIH, CAL/OSHA. 2 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Glyoxal used in cosmetics?

Yes, Glyoxal is also indexed as a cosmetic ingredient under the name Glyoxal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Glyoxal come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Glyoxal have different safety status in cosmetics vs industrial chemicals?

Glyoxal is classified GHS CMR hazard (H341, H332, H315, H319, H317) in the chemicals database but is restricted in EU cosmetics at max 0.05%.

Is Glyoxal used outside industrial chemicals?

Glyoxal also appears in cosmetics, pharmaceutical databases.