Also known as: Ethanedial, 4-01-00-03625, Aerotex glyoxal 40, BRN 1732463, EINECS 203-474-9 (+4 more)
CAS 107-22-2
Glyoxal (CAS 107-22-2) is a chemical substance with GHS signal word Warning; key hazard signal: H341; H332; H315; H319; H317. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC, OSHA.
Glyoxal is classified GHS CMR hazard (H341, H332, H315, H319, H317) in the chemicals database but is restricted in EU cosmetics at max 0.05%.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Muta. 2; Acute Tox. 4 *; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1 | H341; H332; H315; H319; H317 | GHS08; GHS07 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and skin. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol or vapour and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| ACGIH | TWA | 0.1 mg/m³ (inhalable fraction and vapor) [1999] | - | 0.1 | N |
| CAL/OSHA | TWA | 0.1 mg/m³ | - | 0.1 | N |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Europe; Personal care; restricted | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.4 | - | - | inhalation | rat | Regulatory source |
| 5 | mg/kg bw | - | oral | rat | Regulatory source |
| 24 | - | - | - | - | Regulatory source |
| 24 | - | - | inhalation | rat | Regulatory source |
| 40 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 40 | % | - | - | rat | Regulatory source |
| 40 | mg/kg bw/day | - | - | rat | Regulatory source |
| 100 | mg/kg bw/day | - | - | - | Regulatory source |
| 100 | mg/kg bw | - | oral | rat | Regulatory source |
| 107 | mg/kg bw | - | - | - | Regulatory source |
| 107 | mg/kg bw | - | oral | rat | Regulatory source |
| 115 | mg/kg bw | - | oral | rat | Regulatory source |
| 115 | mg/kg bw | - | oral | dog | Regulatory source |
| 132 | mg/kg bw | - | oral | rat | Regulatory source |
| 286.7 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 28 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 32.63 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 92.79 | ug/mL | CV70 | Dermal | - | NTP ICE skin sensitization |
| 396 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 0.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 0.4167 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =0.04 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| =2.96 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 56.5 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 68.2 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 26.7 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 67.8 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 47 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 62.15 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 24.58 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 77 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 80.41 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 87 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 88.6 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 89.1 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 89.12 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 91.7 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 95.6 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 100.9 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 107.5 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 115.9 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 116.9 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 120 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 123.9 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 127.4 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 127.6 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 130.5 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 131.2 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 134.1 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 140.8 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
Showing 50 of 92 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | glyoxal … %; ethandial … % | 203-474-9 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/0876/05 | 21 June 2005 | not safe | Not safe in cosmetics | Potential genotoxin/mutagen; skin sensitiser; cross-links proteins; not suitable for cosmetic use |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Glyoxal (CAS 107-22-2) is classified under EU CLP Annex VI as Muta. 2; Acute Tox. 4 *; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1 with signal word Warning. Hazard statements: H341; H332; H315; H319; H317. Source: EU CLP Annex VI (ECHA).
Glyoxal has 92 NOAEL studies in the database. The lowest reported value is 0.04 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
Glyoxal appears on 4 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides, Indirect additives food contact (10/2018), and 1 more. Source: EPA CPDat.
Occupational exposure limits for Glyoxal are set by ACGIH, CAL/OSHA. 2 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Glyoxal is also indexed as a cosmetic ingredient under the name Glyoxal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Glyoxal is classified GHS CMR hazard (H341, H332, H315, H319, H317) in the chemicals database but is restricted in EU cosmetics at max 0.05%.
Glyoxal also appears in cosmetics, pharmaceutical databases.