Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
to limit the concentration of free formaldehyde, the Expert Panel concluded that Glyoxal is safe for use in products intended to be applied to the nail at concentrations < 1.25%. The available data are insufficient to support the safety for other uses, if any. INTRODUCTION Glyoxal (CAS No. 1
Sensitization Profile
Contact sensitization data for Glyoxal based on clinical patch test studies and IFRA standards.
Source: ESSCA; IVDK; NACDG
Expert Verdict
Formaldehyde releaser classified CMR 1B under CLP; SCCP restricted to 100 ppm; impending US ban; mutagenic in bacterial assays; respiratory sensitization risk in aerosolized products
Regulatory Flags
Frequently Asked Questions
Is Glyoxal safe in cosmetics?
Formaldehyde releaser classified CMR 1B under CLP; SCCP restricted to 100 ppm; impending US ban; mutagenic in bacterial assays; respiratory sensitization risk in aerosolized products The EU classifies Glyoxal as "restricted". Safety rating: POOR. This ingredient has been reviewed by cir.
Is Glyoxal allowed in the EU?
Glyoxal EU regulatory status: restricted. Maximum allowed concentration: 0.05%. This is based on EU Regulation 1223/2009 and its amendments.
What does Glyoxal do in cosmetics?
Glyoxal functions as: Preservative (formaldehyde releaser). It is classified as a cosmetic ingredient in our database. CAS number: 107-22-2.
What is the Margin of Safety for Glyoxal?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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