Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

2-Methyl-2,4-pentanediol

Also known as: Hexylene glycol, 4-01-00-02565, BRN 1098298, Caswell No. 574, EINECS 203-489-0 (+12 more)

CAS 107-41-5

2-Methyl-2,4-pentanediol (CAS 107-41-5) is a chemical substance with GHS signal word Warning; key hazard signal: H315; H319. Key regulatory status: REACH registered, 20 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Hexylene Glycol →

SOURCE NOAEL studies
NOAEL studies
25
SOURCE Chemical inventory jurisdictions
Regulatory lists
20
SOURCE EU CLP Annex VI
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 22 fields
Name
2-Methyl-2,4-pentanediol
CAS Number
107-41-5
Molecular Formula
C6H14O2
InChI Key
SVTBMSDMJJWYQN-UHFFFAOYSA-N
Monoisotopic Mass
118.09938
Synonyms
Hexylene glycol4-01-00-02565BRN 1098298Caswell No. 574EINECS 203-489-0EPA Pesticide Chemical Code 068601Pinakon(+-)-2-Methyl-2,4-pentanediolUNII-KEH0A3F75J1,1,3-trimethyl-1,3-propanediol1,3,3-trimethyl-1,3-propanediol1,3-dimethyl-3-hydroxybutanol

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Skin Irrit. 2; Eye Irrit. 2H315; H319GHS07Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records
FieldValue
Short-term EffectsThe substance is irritating to the eyes, skin and respiratory tract.
Long-term EffectsRepeated or prolonged contact with skin may cause dermatitis.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its aerosol.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 4 records
AgencyMetricValueppmmg/m3Skin
NIOSHCEILING25 ppm (125 mg/m³)25125N
ACGIHTWA25 ppm (vapor fraction) [2016]25-N
ACGIHSTEL50 ppm (vapor fraction), 10 mg/mg³ (inhalable particulate matter, aerosol only) [2016]5010N
CAL/OSHACEILING25 ppm (125 mg/m³)25125N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
SolventSurfactant (surface active agent)Softener and conditionerEmulsifierFragranceViscosity modifierFillerPlasticizerChelating agentAnti-adhesive/cohesiveWetting agent (non-aqueous)Solubility enhancer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 20 records
ListKeywordSource
Europe; Specialty occupational productsDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
SCIL (9/2019)USEPASafer Chemical Ingredients List
consumer_product; EuropeDanish Environmental Protection AgencyDanish EPA
consumer_product; detected; EuropeDanish Environmental Protection AgencyDanish EPA
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
inert_ingredient; non_food_use; PesticidesEPACPCat
Arts and crafts/Office supplies - home office - pens and markers; detected; EuropeDanish Environmental Protection AgencyDanish EPA
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - hair styling and care - shampooDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 25 of 25 studies
ValueUnitEndpointRouteSpeciesSource
=49mg/m3DNEL localinhalationHumanToxValDB GESTIS DNEL
=44.43mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
KEH0A3F75JUNIIFDA UNII substance identifier--openFDA substances
0%Incidence of positive responsesDermalHumanNTP ICE skin sensitization
1.350e+4ug/cm2Induction dose per skin areaDermalHumanNTP ICE skin sensitization
>0.31mg/LLC50Inhalation-NTP ICE acute inhalation
>2000mg/kg bwLD50oralRatNTP ICE acute oral
=3700mg/kg bwLD50oralRatNTP ICE acute oral
=4700mg/kg bwLD50oralRatNTP ICE acute oral
=4790mg/kg bwLD50oralRatNTP ICE acute oral
=800mg/kg bw/dayLELoralRatECHA
=1000mg/kg bw/dayLELoralRabbitECHA
=2000mg/kg bw/dayLELoralRatToxValDB EPA TSCA 8e
=1000mg/kg bw/dayLOAELoralRatECHA
=1200mg/kg bw/dayLOELoralRatToxValDB EPA TSCA 8e
=1600mg/kg bw/dayLOELoralRatToxValDB EPA TSCA 8e
0unitlessModel Score--NTP ICE endocrine
=250mg/kg bw/dayNOAELoralRatECHA
=300mg/kg bw/dayNOAELoralRatECHA
=450mg/kg bw/dayNOAELoralRatECHA
=50mg/kg bw/dayNOELoralRatECHA
=200mg/kg bw/dayNOELoralRatECHA
=500mg/kg bw/dayNOELoralRatECHA
>=1000mg/kg bw/dayNOELoralRatECHA
3unitlessRelative reliability scoreDermalHumanNTP ICE skin sensitization

Showing 25 of 25 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered2-methylpentane-2,4-diol203-489-0ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
solvent
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed HEXYLENE GLYCOL
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 2-Methyl-2,4-pentanediol?

2-Methyl-2,4-pentanediol (CAS 107-41-5) is classified under EU CLP Annex VI as Skin Irrit. 2; Eye Irrit. 2 with signal word Warning. Hazard statements: H315; H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2-Methyl-2,4-pentanediol?

2-Methyl-2,4-pentanediol has 25 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.

What regulatory lists include 2-Methyl-2,4-pentanediol?

2-Methyl-2,4-pentanediol appears on 11 regulatory/inventory lists including Europe; Specialty occupational products, IFRA Transparency, SCIL (9/2019), and 8 more. Source: EPA CPDat.

What are the occupational exposure limits for 2-Methyl-2,4-pentanediol?

Occupational exposure limits for 2-Methyl-2,4-pentanediol are set by NIOSH, ACGIH, CAL/OSHA. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 2-Methyl-2,4-pentanediol used in cosmetics?

Yes, 2-Methyl-2,4-pentanediol is also indexed as a cosmetic ingredient under the name Hexylene Glycol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Methyl-2,4-pentanediol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 2-Methyl-2,4-pentanediol used outside industrial chemicals?

2-Methyl-2,4-pentanediol also appears in cosmetics, pharmaceutical databases.