Also known as: 4-01-00-02565, BRN 1098298, Caswell No. 574, EINECS 203-489-0, EPA Pesticide Chemical Code 068601 (+11 more)
INCI: HEXYLENE GLYCOL
Hexylene Glycol (CAS 107-41-5) is a cosmetic cosmetic ingredient functioning as solvent. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 107-41-5 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Hexylene Glycol.
Calculate MoS for your specific formulation with the MoS Calculator.
2 study endpoints found for Hexylene Glycol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =250 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =300 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Pre-calculated NOAEL → SED → MoS audit trail for Hexylene Glycol across SCCS product categories, with measured dermal absorption where available.
Skin absorption and penetration characteristics of Hexylene Glycol, relevant to systemic exposure and MoS calculations.
Source: CIR
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Inserted via ATP: CLP00
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 13500 | - | - |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
10 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for Hexylene Glycol.
Public NOAEL study rows linked to Hexylene Glycol by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Hexylene Glycol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Hexylene Glycol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Hexylene Glycol functions as: solvent. It is classified as a cosmetic ingredient in our database. CAS number: 107-41-5.
The NOAEL (No Observed Adverse Effect Level) for Hexylene Glycol is =250 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Hexylene Glycol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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