What is the NOAEL for Hexamethyldisiloxane?
Hexamethyldisiloxane has 8 NOAEL studies in the database. The lowest reported value is 53.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Hexamethyldisiloxane
Also known as: Bistrimethylsilyl ether, Bis-trimethylsilyl oxide, EINECS 203-492-7, Fluka AG, Hexamethyl disiloxane (+7 more)
CAS 107-46-0
Hexamethyldisiloxane (CAS 107-46-0) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Hexamethyldisiloxane is classified GHS Danger (H225, H400, H410, H411, H315, H332, H372) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Hexamethyldisiloxane
CAS Number
107-46-0
DTXSID
DTXSID4026769
Molecular Formula
C6H18OSi2
InChI Key
UQEAIHBTYFGYIE-UHFFFAOYSA-N
Monoisotopic Mass
162.089618
Synonyms
Bistrimethylsilyl etherBis-trimethylsilyl oxideEINECS 203-492-7Fluka AGHexamethyl disiloxaneSilane, oxybis(trimethyl-UNII-D7M4659BPU((CH3)3Si)2OBis(trimethylsilyl)etherBis(trimethylsilyl)oxideHMDSOOxybis(trimethylsilane)
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =53.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| D7M4659BPU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D7M4659BPU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D7M4659BPU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D7M4659BPU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 105.9021 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hexamethyldisiloxane | 203-492-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
silicone
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3184090
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
Is Hexamethyldisiloxane used in cosmetics?
Yes, Hexamethyldisiloxane is also indexed as a cosmetic ingredient under the name Disiloxane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hexamethyldisiloxane come from?
Safety data is sourced from EPA ToxValDB, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Hexamethyldisiloxane have different safety status in cosmetics vs industrial chemicals?
Hexamethyldisiloxane is classified GHS Danger (H225, H400, H410, H411, H315, H332, H372) in the chemicals database but is allowed in EU cosmetics.
Is Hexamethyldisiloxane used outside industrial chemicals?
Hexamethyldisiloxane also appears in cosmetics, pharmaceutical, cannabis databases.