Is Disiloxane safe in cosmetics?
Disiloxane has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Disiloxane
Also known as: Bistrimethylsilyl ether, Bis-trimethylsilyl oxide, EINECS 203-492-7, Fluka AG, Hexamethyl disiloxane (+7 more)
INCI: DISILOXANE
Disiloxane (CAS 107-46-0) is a cosmetic cosmetic ingredient functioning as Antifoaming, Skin Conditioning, Solvent. NOAEL 160 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 107-46-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Disiloxane is classified GHS Danger (H225, H400, H410, H411, H315, H332, H372) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antifoaming, Skin Conditioning, Solvent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
trimethyl(trimethylsilyloxy)silane
InChIKey
UQEAIHBTYFGYIE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Listed in FDA CIUCUS. Not restricted by EU Reg 2024/1328 (applies only to D4/D5/D6).
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Disiloxane.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Disiloxane across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Vapors have a very low toxicity for ... humans ... /It/ irritates conjunctiva but does not attack the cornea. | Hexamethyldisiloxane has been noted to give off vapors which are transiently irritating to the conjunctiva, but no injury has been observed.
Source: Hazardous Substances Data Bank (HSDB)
Expert Verdict
Expert safety assessment and concern-level summary for Disiloxane.
Known Synonyms
Bistrimethylsilyl ether
Bis-trimethylsilyl oxide
EINECS 203-492-7
Fluka AG
Hexamethyl disiloxane
Silane, oxybis(trimethyl-
UNII-D7M4659BPU
((CH3)3Si)2O
Bis(trimethylsilyl)ether
Bis(trimethylsilyl)oxide
HMDSO
Oxybis(trimethylsilane)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184090
Frequently Asked Questions
Is Disiloxane allowed in the EU?
Disiloxane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Disiloxane do in cosmetics?
Disiloxane functions as: Antifoaming, Skin Conditioning, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 107-46-0.
Is Disiloxane used outside cosmetics?
Disiloxane also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Disiloxane have different safety status in cosmetics vs industrial chemicals?
Disiloxane is classified GHS Danger (H225, H400, H410, H411, H315, H332, H372) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Disiloxane compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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