What is the GHS hazard classification for Butanoic acid?
Butanoic acid (CAS 107-92-6) is classified under EU CLP Annex VI as Skin Corr. 1B with signal word Danger. Hazard statements: H314. Source: EU CLP Annex VI (ECHA).
Danger
GHS05
NOAEL Data
REACH Registered
Cosmetic Ingredient
Butanoic acid
Also known as: Butyric acid, 4-02-00-00779, BRN 0906770, EINECS 203-532-3, FEMA No. 2221 (+14 more)
CAS 107-92-6
Butanoic acid (CAS 107-92-6) is a chemical substance with GHS signal word Danger; key hazard signal: H314. Key regulatory status: REACH registered, 21 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Butanoic acid is classified GHS Danger (H314) in the chemicals database but is allowed in EU cosmetics.
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Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
22
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Chemical inventory jurisdictions
Regulatory lists
21
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EU CLP Annex VI
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
24 fields
Name
Butanoic acid
CAS Number
107-92-6
Molecular Formula
C4H8O2
InChI Key
FERIUCNNQQJTOY-UHFFFAOYSA-N
Monoisotopic Mass
88.052429
Synonyms
Butyric acid4-02-00-00779BRN 0906770EINECS 203-532-3FEMA No. 2221FEMA Number 2221Kyselina maselnaUNII-40UIR9Q29H1-Butyrate1-Propanecarboxylate1-butanoic acid1-butyric acid
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
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EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Skin Corr. 1B | H314 | GHS05 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
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WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour. |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
19 records
DeodorizerpH regulating agentFlavouring and nutrientFragrancePlasticizerAntioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
21 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Toys and children's products | Scientific Reports | Published Articles |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| detected; Toys and children's products | American Public Health Association | Published Articles |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| detected; Toys and children's products | American Public Health Association | Published Articles |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 22 of 22 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 40.57 | min | Breakthrough Time | Dermal | - | NTP ICE skin irritation |
| =36.8 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 40UIR9Q29H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 675 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| >5 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =7.207e+4 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =0.1 | mM | LOEL | environmental | European Rabbit | ToxValDB ECOTOX |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 4000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 4800 | mg/kg bw/day | NOAEL | oral | syrian hamster | COSMOS DB |
| 6000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 3.4 | % | Viability (240 minutes) | Dermal | - | NTP ICE skin irritation |
| 4.6 | % | Viability (240 minutes) | Dermal | - | NTP ICE skin irritation |
| 6.3 | % | Viability (240 minutes) | Dermal | - | NTP ICE skin irritation |
| 3.8 | % | Viability (3 minutes) | Dermal | - | NTP ICE skin irritation |
| 8 | % | Viability (3 minutes) | Dermal | - | NTP ICE skin irritation |
| 14.8 | % | Viability (3 minutes) | Dermal | - | NTP ICE skin irritation |
| 2.4 | % | Viability (60 minutes) | Dermal | - | NTP ICE skin irritation |
| 2.8 | % | Viability (60 minutes) | Dermal | - | NTP ICE skin irritation |
| 4.7 | % | Viability (60 minutes) | Dermal | - | NTP ICE skin irritation |
Showing 22 of 22 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Butyric acid | 203-532-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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ChEMBL / DailyMed
BUTYRIC ACID
ChEMBL Phase
2
Adverse Events
6
Bioactivity
4
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Butanoic acid?
Butanoic acid has 22 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
What regulatory lists include Butanoic acid?
Butanoic acid appears on 10 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), artificial_saliva; detected; emissions; Europe; Toys and children's products, detected; Toys and children's products, and 7 more. Source: EPA CPDat.
Is Butanoic acid used in cosmetics?
Yes, Butanoic acid is also indexed as a cosmetic ingredient under the name Butyric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Butanoic acid come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Butanoic acid have different safety status in cosmetics vs industrial chemicals?
Butanoic acid is classified GHS Danger (H314) in the chemicals database but is allowed in EU cosmetics.
Is Butanoic acid used outside industrial chemicals?
Butanoic acid also appears in cosmetics, pharmaceutical, cannabis databases.