What is the GHS hazard classification for Butanoic acid?
Butanoic acid (CAS 107-92-6) is classified under EU CLP Annex VI as Skin Corr. 1B with signal word Danger. Hazard statements: H314. Source: EU CLP Annex VI (ECHA).
Danger
GHS05
NOAEL Data
REACH Registered
Cosmetic Ingredient
Butanoic acid
Also known as: Butyric acid, 4-02-00-00779, BRN 0906770, EINECS 203-532-3, FEMA No. 2221 (+14 more)
CAS 107-92-6
Butanoic acid (CAS 107-92-6) is a chemical substance with GHS signal word Danger; key hazard signal: H314. Key regulatory status: REACH registered, 21 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Butanoic acid is classified GHS Danger (H314) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
25
SOURCE
chemical inventory jurisdictions
Regulatory lists
21
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Butanoic acid
CAS Number
107-92-6
DTXSID
DTXSID8021515
Molecular Formula
C4H8O2
InChI Key
FERIUCNNQQJTOY-UHFFFAOYSA-N
Monoisotopic Mass
88.052429
Synonyms
Butyric acid4-02-00-00779BRN 0906770EINECS 203-532-3FEMA No. 2221FEMA Number 2221Kyselina maselnaUNII-40UIR9Q29H1-Butyrate1-Propanecarboxylate1-butanoic acid1-butyric acid
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Skin Corr. 1B | H314 | GHS05 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
19 records
DeodorizerpH regulating agentFlavouring and nutrientFragrancePlasticizerAntioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
21 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Toys and children's products | Scientific Reports | Published Articles |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| detected; Toys and children's products | American Public Health Association | Published Articles |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| detected; Toys and children's products | American Public Health Association | Published Articles |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 25 of 25 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 40.57 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| =36.8 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 40UIR9Q29H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 40UIR9Q29H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 40UIR9Q29H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 40UIR9Q29H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 675 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =72070.7 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =0.1 | mM | LOEL | environmental | European Rabbit | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 4000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 4800 | mg/kg bw/day | NOAEL | oral | syrian hamster | COSMOS_DB |
| 6000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 3.4 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 4.6 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 6.3 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 3.8 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 8 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 14.8 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 2.4 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 2.8 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 4.7 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
Showing 25 of 25 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Butyric acid | 203-532-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BUTYRIC ACID
ChEMBL Phase
2
Adverse Events
6
Bioactivity
4
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Butanoic acid?
Butanoic acid has 25 NOAEL studies in the database. The lowest reported value is 36.8 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
What regulatory lists include Butanoic acid?
Butanoic acid appears on 10 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), artificial_saliva; detected; emissions; Europe; Toys and children's products, detected; Toys and children's products, and 7 more. Source: EPA CPDat.
Is Butanoic acid used in cosmetics?
Yes, Butanoic acid is also indexed as a cosmetic ingredient under the name Butyric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Butanoic acid come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Butanoic acid have different safety status in cosmetics vs industrial chemicals?
Butanoic acid is classified GHS Danger (H314) in the chemicals database but is allowed in EU cosmetics.
Is Butanoic acid used outside industrial chemicals?
Butanoic acid also appears in cosmetics, pharmaceutical, cannabis databases.