Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Butyric Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 4000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 6000 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 4800 mg/kg bw/day | oral | syrian hamster | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Buffering agent with corrosive/irritant potential at high concentrations; strong odor limits practical use levels. At standard buffering concentrations, no systemic concern; final product pH must be documented.
Regulatory Flags
Frequently Asked Questions
Is Butyric Acid safe in cosmetics?
Buffering agent with corrosive/irritant potential at high concentrations; strong odor limits practical use levels. At standard buffering concentrations, no systemic concern; final product pH must be documented. The EU classifies Butyric Acid as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is Butyric Acid allowed in the EU?
Butyric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butyric Acid do in cosmetics?
Butyric Acid functions as: Buffering, Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 107-92-6.
What is the Margin of Safety for Butyric Acid?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Butyric Acid?
The NOAEL (No Observed Adverse Effect Level) for Butyric Acid is 4000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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