Is Butyric Acid safe in cosmetics?
Butyric Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Butyric Acid
Also known as: 4-02-00-00779, BRN 0906770, EINECS 203-532-3, FEMA No. 2221, FEMA Number 2221 (+13 more)
INCI: BUTYRIC ACID
Butyric Acid (CAS 107-92-6) is a cosmetic cosmetic ingredient functioning as Buffering, Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 107-92-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Butyric Acid is classified GHS Danger (H302, H314, H318, H227, H311, H371) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Buffering, Fragrance
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
butanoic acid
InChIKey
FERIUCNNQQJTOY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Adequate at typical cosmetic use levels (< 0.5%)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butyric Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Corrosive
Hazard Class and Category
Skin Corr. 1B
Hazard Statements
- H314 Causes severe skin burns and eye damage
Inserted via ATP: CLP00
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 675 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Additional Ingredient Properties
2 property records from structured ingredient metadata.
fermentation
{"cas_number": "varies", "ingredient_class": "microbial_metabolite", "production_organism": "bacteria", "fermentation_type": "anaerobic", "substrate_feedstock": "glucose, amino acids", "bioactive_compounds_produced": "Butyric Acid", "mechanism_of_action_skin": "cell signaling, antimicrobial, antioxidant, metabolic regulation", "skin_benefit_primary": "antioxidant", "skin_benefit_secondary": "anti_…
microbiome
{"cas_number": "107-92-6", "ingredient_class": "postbiotic", "microbial_source_genus": "Clostridium", "microbial_source_species": "butyricum", "fermentation_substrate": "butter", "live_organism_content": "no", "bioactive_components": "short_chain_fatty_acids", "molecular_weight_range_Da": "88", "pH_of_ingredient": "4.5-5.5", "mechanism_of_action": "barrier_strengthening/immune_modulation", "skin_m…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
ICSC Safety Card
1334
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Vapor: Irritating to eyes, nose, and throat. If inhaled will cause coughing or difficult breathing. Liquid: Will burn skin and eyes.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
87
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BUTYRIC ACID | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/29 | FAS 40-JECFA 49/147
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Deodorizer
Flavouring and nutrient
Fragrance
Plasticizer
pH regulating agent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Butyric Acid.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Butyric Acid by CAS number or substance name.
Studies
3
Lowest NOAEL
133 mg/kg bw/day
Highest NOAEL
133 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
4-02-00-00779
BRN 0906770
EINECS 203-532-3
FEMA No. 2221
FEMA Number 2221
Kyselina maselna
UNII-40UIR9Q29H
1-Butyrate
1-Propanecarboxylate
1-butanoic acid
1-butyric acid
4:0
Butanate
Butanoate
C4:0
CH3-[CH2]2-COOH
N-Butanoate
N-Butyrate
Chemical Function
Deodorizer
pH regulating agent
Flavouring and nutrient
Fragrance
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
artificial_saliva; detected; emissions; Europe; Toys and children's products
detected; Toys and children's products
inert_ingredient; non_food_use; Pesticides
Australia; Food and drug - smoking-related products
detected; Toys and children's products
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Canada; pharmaceutical
consumer_product
inert_ingredient; non_food_use; Pesticides
Australia; Food and drug - smoking-related products
detected; Toys and children's products
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BUTYRIC ACID
ChEMBL ID
CHEMBL14227
Max Phase
2
Adverse Event Associations
6
Frequently Asked Questions
Is Butyric Acid allowed in the EU?
Butyric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butyric Acid do in cosmetics?
Butyric Acid functions as: Buffering, Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 107-92-6.
Is Butyric Acid used outside cosmetics?
Butyric Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Butyric Acid have different safety status in cosmetics vs industrial chemicals?
Butyric Acid is classified GHS Danger (H302, H314, H318, H227, H311, H371) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Butyric Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
Acrolein
Poor
Chemical family
No approved cosmetic function — it is...
Beta-Alanine
Moderate
Chemical family
Skin conditioning, hair conditioning,...
Betaine
Excellent
Chemical family
Humectant, osmolyte, osmoprotectant; ...
Is Butyric Acid in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Butyric Acid in your formulation.