What is the NOAEL for (+-)-Lipoic acid?
(+-)-Lipoic acid has 5 NOAEL studies in the database. The lowest reported value is 73Y7P0K73Y UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(+-)-Lipoic acid
Also known as: 1,2-Dithiolane-3-pentanoic acid, (.+-.)-, 1,2-Dithiolane-3-valeric acid, (.+-.)-, 5-(dithiolan-3-yl)valeric acid, (±)-α-Lipoic acid, Thioctic acid (+15 more)
CAS 1077-28-7
(+-)-Lipoic acid (CAS 1077-28-7) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
(+-)-Lipoic acid
CAS Number
1077-28-7
DTXSID
DTXSID7025508
Molecular Formula
C8H14O2S2
InChI Key
AGBQKNBQESQNJD-UHFFFAOYSA-N
Monoisotopic Mass
206.043522
Synonyms
1,2-Dithiolane-3-pentanoic acid, (.+-.)-1,2-Dithiolane-3-valeric acid, (.+-.)-5-(dithiolan-3-yl)valeric acid(±)-α-Lipoic acidThioctic acid5-19-07-00237BRN 0081853DL-1,2-Dithiolane 3-valeric acid(+-)-1,2-Dithiolane-3-pentanoic acidDL-1,2-Dithiolane-3-valeric acidEINECS 214-071-2DL-alpha-Lipoic acid
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Antioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 73Y7P0K73Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 73Y7P0K73Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 73Y7P0K73Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 73Y7P0K73Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1130 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 5-(dithiolan-3-yl)valeric acid | 214-071-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
LIPOIC ACID, ALPHA
ChEMBL Phase
3
Adverse Events
0
Bioactivity
8
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include (+-)-Lipoic acid?
(+-)-Lipoic acid appears on 3 regulatory/inventory lists including Canada; pharmaceutical, active_ingredient; animal_products; Europe; pharmaceutical; residue, Canada; consumer_product; Substances in Products - Canada (4/2014). Source: EPA CPDat.
Is (+-)-Lipoic acid used in cosmetics?
Yes, (+-)-Lipoic acid is also indexed as a cosmetic ingredient under the name Alpha-Lipoic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (+-)-Lipoic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is (+-)-Lipoic acid used outside industrial chemicals?
(+-)-Lipoic acid also appears in cosmetics, pharmaceutical, food safety databases.