Alpha-Lipoic Acid

INCI: THIOCTIC ACID

CAS Number
1077-28-7
Function
antioxidant, skin-conditioning, anti-aging
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes OTC; dual water and fat solubility; regenerates vitamins C and E in antioxidant network

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Endogenous antioxidant cofactor with dual water and fat solubility that regenerates vitamins C and E in the antioxidant recycling network, exhibits anti-glycation properties, and chelates pro-oxidant transition metals; evidence supports wrinkle reduction at 5% with rare contact sensitization at standard cosmetic concentrations.

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Concern Level: Low

Regulatory Flags

dual-soluble antioxidant-regenerator anti-glycation mild-irritation-risk r-form-preferred

Frequently Asked Questions

Is Alpha-Lipoic Acid safe in cosmetics?

Endogenous antioxidant cofactor with dual water and fat solubility that regenerates vitamins C and E in the antioxidant recycling network, exhibits anti-glycation properties, and chelates pro-oxidant transition metals; evidence supports wrinkle reduction at 5% with rare contact sensitization at standard cosmetic concentrations. The EU classifies Alpha-Lipoic Acid as "permitted". Safety rating: GOOD.

Is Alpha-Lipoic Acid allowed in the EU?

Alpha-Lipoic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Alpha-Lipoic Acid do in cosmetics?

Alpha-Lipoic Acid functions as: antioxidant, skin-conditioning, anti-aging. It is classified as a Antioxidant in our database. CAS number: 1077-28-7.

What is the Margin of Safety for Alpha-Lipoic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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