What is the GHS hazard classification for 4-Methyl-2-pentanol?
4-Methyl-2-pentanol (CAS 108-11-2) is classified under EU CLP Annex VI as Flam. Liq. 3; STOT SE 3 with signal word Warning. Hazard statements: H226; H335. Source: EU CLP Annex VI (ECHA).
Warning
GHS02GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Methyl-2-pentanol
Also known as: M.I.B.C., 4-01-00-01717, BRN 1098268, 1,3-Dimethylbutanol, EINECS 203-551-7 (+10 more)
CAS 108-11-2
4-Methyl-2-pentanol (CAS 108-11-2) is a chemical substance with GHS signal word Warning; key hazard signal: H226; H335. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
View cosmetic safety profile for 4-Methylpentan-2-Ol (MIBC) →
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
4-Methyl-2-pentanol
CAS Number
108-11-2
DTXSID
DTXSID2026781
Molecular Formula
C6H14O
InChI Key
WVYWICLMDOOCFB-UHFFFAOYSA-N
Monoisotopic Mass
102.104465
Synonyms
M.I.B.C.4-01-00-01717BRN 10982681,3-DimethylbutanolEINECS 203-551-7Methylisobutyl carbinol4-Methylpentanol-24-Pentanol, 2-methyl-(+-)-4-Methyl-2-pentanol4-Metilpentan-2-oloAlcohol methyl amyliqueAlcool methyl amylique
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; STOT SE 3 | H226; H335 | GHS02; GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
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ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. Exposure could cause lowering of consciousness. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour and through the skin. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
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OSHA / NIOSH / ACGIH occupational exposure limits
8 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 25 ppm (100 mg/m³) | 25 | 100 | Y |
| NIOSH | TWA | 25 ppm (100 mg/m³) | 25 | 100 | Y |
| NIOSH | STEL | 40 ppm (165 mg/m³) | 40 | 165 | Y |
| ACGIH | TWA | 20 ppm (83 mg/m³) [2020] | 20 | 83 | N |
| ACGIH | STEL | 40 ppm (167 mg/m³) [2020] | 40 | 167 | N |
| CAL/OSHA | TWA | 25 ppm (100 mg/m³) | 25 | 100 | Y |
| CAL/OSHA | STEL | 40 ppm (165 mg/m³) | 40 | 165 | Y |
| NIOSH | IDLH | 400 ppm | 400 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
8 records
FragranceFlavouring and nutrientSolventChemical reaction regulator
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =83 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8U34XJK0R0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8U34XJK0R0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8U34XJK0R0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8U34XJK0R0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >16 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =2590 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2600 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =3 | mg/m3 | RfC | inhalation | Human | ToxValDB_RSL |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-methylpentan-2-ol | 203-551-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL448896
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for 4-Methyl-2-pentanol?
4-Methyl-2-pentanol has 10 NOAEL studies in the database. The lowest reported value is 83 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
What regulatory lists include 4-Methyl-2-pentanol?
4-Methyl-2-pentanol appears on 4 regulatory/inventory lists including air; detected; emissions; Europe; Other direct contact consumer goods, IFRA Transparency, consumer_product, and 1 more. Source: EPA CPDat.
What are the occupational exposure limits for 4-Methyl-2-pentanol?
Occupational exposure limits for 4-Methyl-2-pentanol are set by OSHA, NIOSH, ACGIH. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is 4-Methyl-2-pentanol used in cosmetics?
Yes, 4-Methyl-2-pentanol is also indexed as a cosmetic ingredient under the name 4-Methylpentan-2-Ol (MIBC). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Methyl-2-pentanol come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-Methyl-2-pentanol used outside industrial chemicals?
4-Methyl-2-pentanol also appears in cosmetics, pharmaceutical, cannabis databases.