Also known as: 2-Propanamine, N-(1-methylethyl)-, N,N-Diisopropylamine, EINECS 203-558-5, N-Isopropyl-1-amino-2-methylethane, UNII-BR9JLI40NO
CAS 108-18-9
Diisopropylamine (CAS 108-18-9) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H332; H302; H314. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Diisopropylamine is classified GHS Danger (H225, H332, H302, H314) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B | H225; H332; H302; H314 | GHS02; GHS07; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour Harmful if swallowed Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life |
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Contact of the vapour with the eyes may cause visual disturbances. Exposure could cause asphyxiation due to swelling in the throat. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest. See Notes. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. |
| Routes of Exposure | Serious local effects by all routes of exposure. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 5 ppm (20 mg/m³) | 5 | 20 | Y |
| NIOSH | TWA | 5 ppm (20 mg/m³) | 5 | 20 | Y |
| ACGIH | TWA | 5 ppm [1979] | 5 | - | Y |
| CAL/OSHA | TWA | 5 ppm (20 mg/m³) | 5 | 20 | Y |
| NIOSH | IDLH | 200 ppm | 200 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =5 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| BR9JLI40NO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BR9JLI40NO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BR9JLI40NO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BR9JLI40NO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >4.1362 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 4.8 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 5.35 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 10.6218 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =310 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =420 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =540 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =770 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =45526.7 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =100 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_TX_TCEQ |
| =256.605 | mg/m3 | LOAEL | inhalation | Mouse | ToxValDB_TX_TCEQ |
Showing 16 of 16 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diisopropylamine | 203-558-5 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Diisopropylamine (CAS 108-18-9) is classified under EU CLP Annex VI as Flam. Liq. 2; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B with signal word Danger. Hazard statements: H225; H332; H302; H314. Source: EU CLP Annex VI (ECHA).
Diisopropylamine has 16 NOAEL studies in the database. The lowest reported value is 5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Diisopropylamine appears on 1 regulatory/inventory list including detected; Europe; Other direct contact consumer goods. Source: EPA CPDat.
Occupational exposure limits for Diisopropylamine are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Diisopropylamine is also indexed as a cosmetic ingredient under the name Diisopropylamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Diisopropylamine is classified GHS Danger (H225, H332, H302, H314) in the chemicals database but is allowed in EU cosmetics.
Diisopropylamine also appears in cosmetics, pharmaceutical databases.