Good Cosmetic Ingredient NOAEL Data GHS Classified SCCS/CIR Reviewed

Diisopropylamine

INCI: DIISOPROPYLAMINE

CAS Number

108-18-9

Function

pH adjuster

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes Permitted — CIR Expert Panel concluded safe as used; must not be used with N-nitrosating agents

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

moderate

Sensitization

low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Diisopropylamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	15 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	>=150 mg/kg bw/day	dermal	rat	dermal	REACH
NOAEL	150 mg/kg bw/day	dermal	rat	dermal	REACH
NOAEL	30 mg/kg bw/day	oral	rat	oral	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

flam;flame; corr; excl mark;warn

Hazard Statements

Highly flammable liquid and vapour Harmful if swallowed Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life

Short-term Exposure Effects

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Contact of the vapour with the eyes may cause visual disturbances. Exposure could cause asphyxiation due to swelling in the throat. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest. See Notes.

Long-term Exposure Effects

Repeated or prolonged contact with skin may cause dermatitis.

Routes of Exposure

Serious local effects by all routes of exposure.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir York 0 1995

Verdict: unknown

Expert Verdict

pH adjuster permitted in cosmetics with CIR safety approval; avoid use with N-nitrosating agents.

⚠️

Concern Level: Low

Frequently Asked Questions

Is Diisopropylamine safe in cosmetics?

pH adjuster permitted in cosmetics with CIR safety approval; avoid use with N-nitrosating agents. The EU classifies Diisopropylamine as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is Diisopropylamine allowed in the EU?

Diisopropylamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diisopropylamine do in cosmetics?

Diisopropylamine functions as: pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 108-18-9.

What is the Margin of Safety for Diisopropylamine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Diisopropylamine?

The NOAEL (No Observed Adverse Effect Level) for Diisopropylamine is 15 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.

Is Diisopropylamine classified as hazardous under GHS?

Diisopropylamine carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Harmful if swallowed Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Diisopropylamine compliance across multiple jurisdictions:

🔬

Ingredient Decoder

Paste a full ingredient list for instant analysis

🌸

82 Allergen Checker

Check for EU declarable fragrance allergens

🧪

Substance Compliance

Check compliance across 55 jurisdictions

🧮

MoS Calculator

Calculate Margin of Safety using SCCS methodology

⚗️

Heavy Metal Limits

Compare limits across jurisdictions

Related Ingredients

Pregnane

Moderate

Polyacrylate-6

Good

Saccharum Officinarum Wax

Excellent

Hydroxyethyl Isobutyl Piperidine Carboxylate (Icaridin/Picaridin)

Good

Silver Acetylmethionate

Moderate

Browse all 30,000+ ingredients →

📱

Is Diisopropylamine in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Diisopropylamine in your formulation.

Ingredient Decoder MoS Calculator