Is Diisopropylamine safe in cosmetics?
Diisopropylamine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. This ingredient has been reviewed by CIR Safety Assessment.
Diisopropylamine
Also known as: 2-Propanamine, N-(1-methylethyl)-, N,N-Diisopropylamine, EINECS 203-558-5, N-Isopropyl-1-amino-2-methylethane, UNII-BR9JLI40NO
INCI: DIISOPROPYLAMINE
Diisopropylamine (CAS 108-18-9) is a cosmetic cosmetic ingredient functioning as pH adjuster. NOAEL 15 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Cross-Vertical Regulatory Divergence
Diisopropylamine is classified GHS Danger (H225, H302, H314, H318, H331, H332, H335, H371) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
pH adjuster
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
N-propan-2-ylpropan-2-amine
InChIKey
UAOMVDZJSHZZME-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — CIR Expert Panel concluded safe as used; must not be used with N-nitrosating agents
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diisopropylamine.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameCorrExcl markWarn
Hazard Statements
Highly flammable liquid and vapour Harmful if swallowed Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Contact of the vapour with the eyes may cause visual disturbances. Exposure could cause asphyxiation due to swelling in the throat. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest. See Notes.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis.
Routes of Exposure
Serious local effects by all routes of exposure.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
CIR Safety Assessment
York
0 1995
Verdict: unknown
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diisopropylamine across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / IrritantCorrosive
Hazard Class and Category
Flam. Liq. 2; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B
Hazard Statements
- H225 Highly flammable liquid and vapour
- H332 Harmful if inhaled
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
Specific Concentration Limits / M-factors
STOT SE 3; H335: C ≥ 5.0%
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0449
Source: WHO/JECFA
Skin Eye Respiratory Irritation
Diisopropylamine vapor is a respiratory irritant and a severe eye irritant. | A skin and severe eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
pH regulating agent
Editorial summary
Preliminary editorial summary for Diisopropylamine — not a computed safety verdict. See the sourced toxicological data above.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diisopropylamine by CAS number or substance name.
Studies
15
Lowest NOAEL
15 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA
Known Synonyms
2-Propanamine, N-(1-methylethyl)-
N,N-Diisopropylamine
EINECS 203-558-5
N-Isopropyl-1-amino-2-methylethane
UNII-BR9JLI40NO
Chemical Function
pH regulating agent
Regulatory Lists
detected; Europe; Other direct contact consumer goods
detected; Europe; Other direct contact consumer goods
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1450356
Frequently Asked Questions
Is Diisopropylamine allowed in the EU?
Diisopropylamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diisopropylamine do in cosmetics?
Diisopropylamine functions as: pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 108-18-9.
Is Diisopropylamine classified as hazardous under GHS?
Diisopropylamine carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Harmful if swallowed Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Diisopropylamine used outside cosmetics?
Diisopropylamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Diisopropylamine have different safety status in cosmetics vs industrial chemicals?
Diisopropylamine is classified GHS Danger (H225, H302, H314, H318, H331, H332, H335, H371) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Diisopropylamine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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