Also known as: 2,5-Furandione, dihydro-, 5-17-11-00006, BRN 0108441, EINECS 203-570-0, NCI-C55696 (+4 more)
CAS 108-30-5
Succinic anhydride (CAS 108-30-5) is a chemical substance with GHS signal word Danger; key hazard signal: H302; H314; H318; H334; H317. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC.
Succinic anhydride is classified GHS Danger (H302, H314, H318, H334, H317) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 15, Sup 7 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4; Skin Corr. 1; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1 | H302; H314; H318; H334; H317 | GHS07; GHS05; GHS08 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Harmful if swallowed Causes serious eye irritation |
| Short-term Effects | The substance is severely irritating to the eyes. The substance is irritating to the respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 6RF4O17Z8J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6RF4O17Z8J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6RF4O17Z8J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6RF4O17Z8J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =1510 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1794 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2157 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| ~25 | mg/kg bw/day | LEL | injection | Mouse | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | LEL | injection | Mouse | ToxValDB_ECHA_IUCLID |
| =200 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =75 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| >100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >150 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| 75 | mg/kg bw/day | Top dose | Gavage | Mouse | NTP_ICE_cancer |
| 100 | mg/kg | Top dose | Gavage | Rat | NTP_ICE_cancer |
| 150 | mg/kg bw/day | Top dose | Gavage | Mouse | NTP_ICE_cancer |
Showing 22 of 22 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Succinic anhydride | 203-570-0 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
1 food-safety record found.
View full food safety profile →Succinic anhydride (CAS 108-30-5) is classified under EU CLP Annex VI as Acute Tox. 4; Skin Corr. 1; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1 with signal word Danger. Hazard statements: H302; H314; H318; H334; H317. Source: EU CLP Annex VI (ECHA).
Succinic anhydride has 22 NOAEL studies in the database. The lowest reported value is 6RF4O17Z8J UNII. Source: openFDA substances.
Succinic anhydride appears on 1 regulatory/inventory list including food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Succinic anhydride is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Succinic anhydride is also indexed as a cosmetic ingredient under the name Succinic Anhydride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Succinic anhydride is classified GHS Danger (H302, H314, H318, H334, H317) in the chemicals database but is allowed in EU cosmetics.
Succinic anhydride also appears in cosmetics, pharmaceutical, food safety databases.