Is Succinic Anhydride safe in cosmetics?
Succinic Anhydride has a safety rating of "POOR" in our database. EU status: permitted. US status: restricted. 1 toxicological study endpoint(s) are available in our database.
Succinic Anhydride
Also known as: 2,5-Furandione, dihydro-, 5-17-11-00006, BRN 0108441, EINECS 203-570-0, NCI-C55696 (+4 more)
INCI: SUCCINIC ANHYDRIDE
Succinic Anhydride (CAS 108-30-5) is a cosmetic cosmetic ingredient functioning as Buffering agent, pH adjuster. NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 108-30-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Succinic Anhydride is classified GHS Danger (H302, H314, H317, H318, H319, H334, H335, H402) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Buffering agent, pH adjuster
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
oxolane-2,5-dione
InChIKey
RINCXYDBBGOEEQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted; permitted under general cosmetic provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Succinic Anhydride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Succinic Anhydride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =75 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Pictograms
Excl markWarn
Hazard Statements
Harmful if swallowed Causes serious eye irritation
Short-term Exposure Effects
The substance is severely irritating to the eyes. The substance is irritating to the respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Succinic Anhydride across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
15, Sup 7
Evaluation Year
1987
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Harmful / IrritantCorrosiveHealth Hazard
Hazard Class and Category
Acute Tox. 4; Skin Corr. 1; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
Hazard Statements
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
- H318 Causes serious eye damage
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
- H317 May cause an allergic skin reaction
Inserted via ATP: ATP13
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (5)
Carcinogen Classification
Succinic anhydride | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 15: (1977) Some Fumigants, the Herbicides 2,4-D and 2,4,5-T, Chlorinated Dibenzodioxins and Miscellaneous Industrial Chemicals | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
Succinic Anhydride | TR-373: Toxicology and Carcinogenesis Studies of Succinic Anhydride (CASRN 108-30-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1990 ) | 06/27/89 | No Evidence | No Evidence | No Evidence | No Evidence | Under the conditions of these 2-year studies, there was no evidence of carcinogenic activity of succinic anhydride for male or female F344/N rats given 50 or 10
Source: NTP Technical Reports
Evidence for Carcinogenicity
No data are available in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
1312
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
The substance irritates the eyes, the skin and the respiratory tract. | A severe eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dispersing agent
No specific technical function
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Succinic Anhydride.
Regulatory Flags
potential-allergen
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Succinic Anhydride by CAS number or substance name.
Studies
16
Lowest NOAEL
55 mg/kg bw/day
Highest NOAEL
250 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
2,5-Furandione, dihydro-
5-17-11-00006
BRN 0108441
EINECS 203-570-0
NCI-C55696
Bernsteinsaure-anhydrid
UNII-6RF4O17Z8J
2,5-dioxotetrahydrofuran
dihydrofuran-2,5-dione
Chemical Function
Dispersing agent
No specific technical function
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1370164
Frequently Asked Questions
Is Succinic Anhydride allowed in the EU?
Succinic Anhydride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Succinic Anhydride do in cosmetics?
Succinic Anhydride functions as: Buffering agent, pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 108-30-5.
What is the NOAEL for Succinic Anhydride?
The NOAEL (No Observed Adverse Effect Level) for Succinic Anhydride is =75 mg/kg bw/day based on a chronic study via oral route in Mouse. Source: ToxValDB_ECHA_IUCLID.
Is Succinic Anhydride classified as hazardous under GHS?
Succinic Anhydride carries a GHS signal word of "WARNING". Hazard statements: Harmful if swallowed Causes serious eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Succinic Anhydride used outside cosmetics?
Succinic Anhydride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Succinic Anhydride have different safety status in cosmetics vs industrial chemicals?
Succinic Anhydride is classified GHS Danger (H302, H314, H317, H318, H319, H334, H335, H402) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Succinic Anhydride compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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