Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Succinic Anhydride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 150 mg/kg bw/day | oral | mouse | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Corrosive (H314 severe skin burns/eye damage); H318 serious eye damage; H317 skin sensitizer; H334 respiratory sensitizer; H302 harmful if swallowed; must hydrolyze completely to succinic acid in final formulation to be safe
Regulatory Flags
Frequently Asked Questions
Is Succinic Anhydride safe in cosmetics?
Corrosive (H314 severe skin burns/eye damage); H318 serious eye damage; H317 skin sensitizer; H334 respiratory sensitizer; H302 harmful if swallowed; must hydrolyze completely to succinic acid in final formulation to be safe The EU classifies Succinic Anhydride as "permitted". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.
Is Succinic Anhydride allowed in the EU?
Succinic Anhydride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Succinic Anhydride do in cosmetics?
Succinic Anhydride functions as: Buffering agent, pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 108-30-5.
What is the Margin of Safety for Succinic Anhydride?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Succinic Anhydride?
The NOAEL (No Observed Adverse Effect Level) for Succinic Anhydride is 100 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Is Succinic Anhydride classified as hazardous under GHS?
Succinic Anhydride carries a GHS signal word of "WARNING". Hazard statements: Harmful if swallowed Causes serious eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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