Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Propylene carbonate

Also known as: 1,3-Dioxolan-2-one, 4-methyl-, 5-19-04-00021, BRN 0107913, Carbonic acid, cyclic propylene ether, Dipropylene carbonate (+4 more)

CAS 108-32-7

Propylene carbonate (CAS 108-32-7) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Propylene Carbonate →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 15 fields

Name

Propylene carbonate

CAS Number

108-32-7

DTXSID

DTXSID2026789

Molecular Formula

C4H6O3

InChI Key

RUOJZAUFBMNUDX-UHFFFAOYSA-N

Monoisotopic Mass

102.031694

Synonyms

1,3-Dioxolan-2-one, 4-methyl-5-19-04-00021BRN 0107913Carbonic acid, cyclic propylene etherDipropylene carbonateEINECS 203-572-14-Methyldioxalone-2Propylenester kyseliny uhliciteUNII-8D08K3S51E

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Eye Irrit. 2	H319	GHS07	Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

Solubility enhancerSolventViscosity modifierFragranceFillerCatalyst

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
IFRA Transparency	IFRA	IFRA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
Cleaning products and household care - oven - oven cleaner; Europe	Danish Environmental Protection Agency	Danish EPA
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 24 of 24 studies

Value	Unit	Endpoint	Route	Species	Source
=20	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
=70.53	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
8D08K3S51E	UNII	FDA UNII substance identifier	-	-	openFDA substances
8D08K3S51E	UNII	FDA UNII substance identifier	-	-	openFDA substances
8D08K3S51E	UNII	FDA UNII substance identifier	-	-	openFDA substances
8D08K3S51E	UNII	FDA UNII substance identifier	-	-	openFDA substances
>5	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=3000	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=3000	mg/kg bw/day	LEL	oral	rat (sprague dawley; Sprague Dawley)	ToxRefDB_ToxRefDB_v3_pod.csv
=5000	mg/kg bw/day	LEL	oral	rat (sprague dawley; Sprague Dawley)	ToxRefDB_ToxRefDB_v3_pod.csv
3000	mg/kg bw/day	LOEL	Oral	Rat	NTP_ICE_dart
3000	mg/kg bw/day	LOEL	Oral	Rat	NTP_ICE_dart
3000	mg/kg bw/day	LOEL	Oral	Rat	NTP_ICE_dart
3000	mg/kg bw/day	LOEL	Oral	Rat	NTP_ICE_dart
5000	mg/kg bw/day	LOEL	Oral	Rat	NTP_ICE_dart
5000	mg/kg bw/day	LOEL	Oral	Rat	NTP_ICE_dart
5000	mg/kg bw/day	LOEL	Oral	Rat	NTP_ICE_dart
5000	mg/kg bw/day	LOEL	Oral	Rat	NTP_ICE_dart
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=1000	mg/kg bw/day	NEL	oral	Rat	ToxValDB_ToxRefDB
=1000	mg/kg bw/day	NEL	oral	rat (sprague dawley; Sprague Dawley)	ToxRefDB_ToxRefDB_v3_pod.csv
=3000	mg/kg bw/day	NEL	oral	Rat	ToxValDB_ToxRefDB
=1000	mg/m3	NOAEL	inhalation	Rat	ToxValDB_HPVIS
=5000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_HPVIS

Showing 24 of 24 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Propylene carbonate	203-572-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL PROPYLENE CARBONATE

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Propylene carbonate?

Propylene carbonate (CAS 108-32-7) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Propylene carbonate?

Propylene carbonate has 24 NOAEL studies in the database. The lowest reported value is 20 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Propylene carbonate?

Propylene carbonate appears on 6 regulatory/inventory lists including IFRA Transparency, inert_ingredient; non_food_use; Pesticides, CEDI, and 3 more. Source: EPA CPDat.

Is Propylene carbonate used in cosmetics?

Yes, Propylene carbonate is also indexed as a cosmetic ingredient under the name Propylene Carbonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Propylene carbonate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is Propylene carbonate used outside industrial chemicals?

Propylene carbonate also appears in cosmetics, pharmaceutical databases.