What is the GHS hazard classification for Propylene carbonate?
Propylene carbonate (CAS 108-32-7) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Propylene carbonate
Also known as: 1,3-Dioxolan-2-one, 4-methyl-, 5-19-04-00021, BRN 0107913, Carbonic acid, cyclic propylene ether, Dipropylene carbonate (+4 more)
CAS 108-32-7
Propylene carbonate (CAS 108-32-7) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
15
SOURCE
Chemical inventory jurisdictions
Regulatory lists
6
SOURCE
EU CLP Annex VI
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Propylene carbonate
CAS Number
108-32-7
Molecular Formula
C4H6O3
InChI Key
RUOJZAUFBMNUDX-UHFFFAOYSA-N
Monoisotopic Mass
102.031694
Synonyms
1,3-Dioxolan-2-one, 4-methyl-5-19-04-00021BRN 0107913Carbonic acid, cyclic propylene etherDipropylene carbonateEINECS 203-572-14-Methyldioxalone-2Propylenester kyseliny uhliciteUNII-8D08K3S51E
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Eye Irrit. 2 | H319 | GHS07 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Solubility enhancerSolventViscosity modifierFragranceFillerCatalyst
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Cleaning products and household care - oven - oven cleaner; Europe | Danish Environmental Protection Agency | Danish EPA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =20 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| =70.53 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 8D08K3S51E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >5 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =3000 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =3000 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
| =5000 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
| 3000 | mg/kg bw/day | LOEL | Oral | Rat | NTP ICE dart |
| 5000 | mg/kg bw/day | LOEL | Oral | Rat | NTP ICE dart |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| =1000 | mg/kg bw/day | NEL | oral | Rat | ToxValDB ToxRefDB |
| =1000 | mg/kg bw/day | NEL | oral | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
| =3000 | mg/kg bw/day | NEL | oral | Rat | ToxValDB ToxRefDB |
| =1000 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB HPVIS |
| =5000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB HPVIS |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Propylene carbonate | 203-572-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Rheology Modifier
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
PROPYLENE CARBONATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What is the NOAEL for Propylene carbonate?
Propylene carbonate has 15 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
What regulatory lists include Propylene carbonate?
Propylene carbonate appears on 6 regulatory/inventory lists including IFRA Transparency, inert_ingredient; non_food_use; Pesticides, CEDI, and 3 more. Source: EPA CPDat.
Is Propylene carbonate used in cosmetics?
Yes, Propylene carbonate is also indexed as a cosmetic ingredient under the name Propylene Carbonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Propylene carbonate come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Propylene carbonate used outside industrial chemicals?
Propylene carbonate also appears in cosmetics, pharmaceutical databases.